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Tbio
VWA1
von Willebrand factor A domain-containing protein 1

Protein Summary
Description
Promotes matrix assembly. VWA1 belongs to the von Willebrand factor (VWF; MIM 613160) A (VWFA) domain superfamily of extracellular matrix proteins and appears to play a role in cartilage structure and function (Fitzgerald et al., 2002 [PubMed 12062410]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338660
  • ENSP00000423404
  • ENSG00000179403
  • ENST00000476993
  • ENSP00000417185

Symbol
  • WARP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.63
histone modification site profile
0.62
tissue
0.6
transcription factor
0.53
small molecule perturbation
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.89   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390.89   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
CDCP1
Tbio
Novelty:  0.01385067
p_int:  0.999999653
p_ni:  3.46e-7
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
SDF2L1
Tbio
Novelty:  0.12184663
p_int:  0.999992017
p_ni:  0.000007982
p_wrong:  1e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
DEFA6
Tbio
Novelty:  0.0363171
p_int:  0.999982285
p_ni:  0.000017715
Score:  0.186
Data Source:  BioPlex,STRINGDB
PDIA6
Tchem
Family:  Enzyme
Novelty:  0.01692178
p_int:  0.999958994
p_ni:  0.000041005
p_wrong:  2e-9
Score:  0.92
Data Source:  BioPlex,STRINGDB
LAIR2
Tbio
Novelty:  0.06117644
p_int:  0.999956457
p_ni:  0.000043513
p_wrong:  3e-8
Data Source:  BioPlex
MINPP1
Tbio
Family:  Enzyme
Novelty:  0.02584444
p_int:  0.999946194
p_ni:  0.00004866
p_wrong:  0.000005146
Score:  0.165
Data Source:  BioPlex,STRINGDB
CNPY2
Tbio
Novelty:  0.090889
p_int:  0.99991428
p_ni:  0.000085717
p_wrong:  2e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
RCN1
Tbio
Novelty:  0.00857135
p_int:  0.999888719
p_ni:  0.00011128
Score:  0.92
Data Source:  BioPlex,STRINGDB
CCL14
Tbio
Novelty:  0.0103752
p_int:  0.999526649
p_ni:  0.000473347
p_wrong:  4e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.99936728
p_ni:  0.000606336
p_wrong:  0.000026384
Score:  0.156
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
2
2
52.7
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
2
52.7
heel bone mineral density
1
6.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
von Willebrand factor A domain containing 1
701765
Mouse
MGI:2179729
246228
Rat
RGD:1311476
298683
Dog
von Willebrand factor A domain containing 1
VGNC:48318
607112
Cow
von Willebrand factor A domain containing 1
VGNC:36850
505917
Species
Name
OMA
EggNOG
Inparanoid
Macaque
von Willebrand factor A domain containing 1
Mouse
Rat
Dog
von Willebrand factor A domain containing 1
Cow
von Willebrand factor A domain containing 1
Publication Statistics
PubMed Score 390.89
PubMed score by year
PubTator Score 15.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title