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Tbio
VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

Protein Summary
Description
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554659
  • ENSP00000450731
  • ENSG00000100568

Symbol
  • VTI1
  • VTI1L
  • VTI1L1
  • VTI2
  • VTI1
  • VTI2
  • VTI1L
  • v-SNARE
  • vti1-rp1
  • VTI1-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.99
disease perturbation
0.98
cellular component
0.89
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.64   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0