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Tbio
VTI1A
Vesicle transport through interaction with t-SNAREs homolog 1A

Protein Summary
Description
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular func ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393077
  • ENSP00000376792
  • ENSG00000151532
  • ENST00000432306
  • ENSP00000395017

Symbol
  • MMDS3
  • MVti1
  • VTI1RP2
  • Vti1-rp2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
histone modification site profile
0.91
cellular component
0.85
cell type or tissue
0.77
interacting protein
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.22   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.22   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999999529
p_ni:  4.62e-7
p_wrong:  9e-9
Score:  0.978
Data Source:  BioPlex,STRINGDB
CLEC12A
Tbio
Novelty:  0.01478908
p_int:  0.999995342
p_ni:  0.000004657
p_wrong:  1e-9
Score:  0.707
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999988421
p_ni:  0.000011437
p_wrong:  1.42e-7
Score:  0.991
Data Source:  BioPlex,STRINGDB
STX6
Tbio
Novelty:  0.01494028
p_int:  0.999970335
p_ni:  0.000029635
p_wrong:  3e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.999898682
p_ni:  0.000100106
p_wrong:  0.000001212
Score:  0.735
Data Source:  BioPlex,STRINGDB
HAUS1
Tbio
Novelty:  0.11356375
p_int:  0.999800125
p_ni:  0.000196275
p_wrong:  0.000003599
Score:  0.656
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.998333671
p_ni:  0.000062187
p_wrong:  0.001604142
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
STX16
Tbio
Novelty:  0.02462523
Score:  0.996
Data Source:  Reactome,STRINGDB
STX10
Tbio
Novelty:  0.05193552
Score:  0.993
Data Source:  Reactome,STRINGDB
YKT6
Tbio
Novelty:  0.01591063
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
2
1.1
93.9
3
2
2
1.3
93.5
mean platelet volume
3
3
6
88.7
mathematical ability
4
3
6
83.8
electrocardiography
1
1
4
83.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
93.9
2
1.3
93.5
mean platelet volume
6
88.7
mathematical ability
6
83.8
electrocardiography
4
83.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1855699
53611
Rat
RGD:621490
65277
Dog
vesicle transport through interaction with t-SNAREs 1A
VGNC:48316
100685447
Horse
vesicle transport through interaction with t-SNAREs 1A [Source:HGNC Symbol;Acc:HGNC:17792]
Cow
vesicle transport through interaction with t-SNAREs 1A
780850
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
vesicle transport through interaction with t-SNAREs 1A
Horse
vesicle transport through interaction with t-SNAREs 1A [Source:HGNC Symbol;Acc:HGNC:17792]
Cow
vesicle transport through interaction with t-SNAREs 1A
Publication Statistics
PubMed Score 25.22
PubMed score by year
PubTator Score 20.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title