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Tbio
VTCN1
V-set domain-containing T-cell activation inhibitor 1

Protein Summary
Description
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328189
  • ENSP00000328168
  • ENSG00000134258
  • ENST00000369458
  • ENSP00000358470
  • ENST00000539893
  • ENSP00000444724

Symbol
  • B7H4
  • B7X
  • B7H4
  • B7S1
  • B7-H4
  • B7h.5
  • VCTN1
  • PRO1291
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.71
cell line
0.61
biological term
0.6
gene perturbation
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.19   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 729   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.19   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 729   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
NCALD
Tbio
Novelty:  0.03665351
p_int:  0.995375202
p_ni:  0.004621709
p_wrong:  0.000003089
Score:  0.517
Data Source:  BioPlex,STRINGDB
BTLA
Tbio
Novelty:  0.00770048
Score:  0.961
Data Source:  STRINGDB
PDCD1LG2
Tchem
Novelty:  0.00188515
Score:  0.797
Data Source:  STRINGDB
ICOSLG
Tbio
Novelty:  0.00693966
Score:  0.696
Data Source:  STRINGDB
CD80
Tclin
Novelty:  0.00031181
Score:  0.677
Data Source:  STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.675
Data Source:  STRINGDB
CD86
Tclin
Novelty:  0.00029965
Score:  0.653
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.644
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.635
Data Source:  STRINGDB
CD28
Tbio
Novelty:  0.00036482
Score:  0.612
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
1
1
31.4
self rated health
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
31.4
self rated health
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
V-set domain containing T cell activation inhibitor 1
VGNC:1723
469433
Macaque
V-set domain containing T-cell activation inhibitor 1
714123
Mouse
MGI:3039619
242122
Rat
RGD:1311204
295322
Dog
V-set domain containing T cell activation inhibitor 1
VGNC:48315
483140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
V-set domain containing T cell activation inhibitor 1
Macaque
V-set domain containing T-cell activation inhibitor 1
Mouse
Rat
Dog
V-set domain containing T cell activation inhibitor 1
Publication Statistics
PubMed Score 245.19
PubMed score by year
PubTator Score 138.15
PubTator score by year
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Related Publications
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PMID
Year
Title