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Tbio
VSTM2A
V-set and transmembrane domain-containing protein 2A

Protein Summary
Description
Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302287
  • ENSP00000303108
  • ENSG00000170419
  • ENST00000407838
  • ENSP00000384967

Symbol
  • VSTM2
  • VSTM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
protein domain
0.58
chemical
0.41
virus perturbation
0.41
cell line
0.39


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
ACAD8
Tbio
Family:  Enzyme
Novelty:  0.05735881
p_int:  0.996051445
p_ni:  0.003948555
Score:  0.517
Data Source:  BioPlex,STRINGDB
ZNF713
Tdark
Family:  TF
Novelty:  0.53817745
Score:  0.645
Data Source:  STRINGDB
SULT4A1
Tbio
Family:  Enzyme
Novelty:  0.02455678
Score:  0.624
Data Source:  STRINGDB
LONRF2
Tdark
Family:  Enzyme
Novelty:  1.01811251
Score:  0.623
Data Source:  STRINGDB
PNMA8A
Tdark
Novelty:  0.95674878
Score:  0.621
Data Source:  STRINGDB
LANCL2
Tchem
Novelty:  0.06086418
Score:  0.617
Data Source:  STRINGDB
SEPT14
Tbio
Novelty:  0.07155096
Score:  0.605
Data Source:  STRINGDB
PGBD5
Tdark
Novelty:  0.15960609
Score:  0.588
Data Source:  STRINGDB
VOPP1
Tbio
Novelty:  0.0259321
Score:  0.579
Data Source:  STRINGDB
SH3RF2
Tbio
Family:  Enzyme
Novelty:  0.14257663
Score:  0.569
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
61
educational attainment
1
1
1
8.2
self reported educational attainment
1
1
1
4.4
cognitive function measurement
1
1
1
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
61
educational attainment
1
8.2
self reported educational attainment
1
4.4
cognitive function measurement
1
1.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
V-set and transmembrane domain containing 2A
VGNC:14113
463414
Macaque
V-set and transmembrane domain containing 2A
705954
Mouse
MGI:2384826
211739
Rat
RGD:1596197
689106
Dog
V-set and transmembrane domain containing 2A
VGNC:48309
608324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
V-set and transmembrane domain containing 2A
Macaque
V-set and transmembrane domain containing 2A
Mouse
Rat
Dog
V-set and transmembrane domain containing 2A
Publication Statistics
PubMed Score 5.20
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title