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Tbio
VSTM1
V-set and transmembrane domain-containing protein 1

Protein Summary
Description
Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17). Isoform 1: Inhibitory immune receptor involved in the regulation of phagocytes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338372
  • ENSP00000343366
  • ENSG00000189068
  • ENST00000376626
  • ENSP00000365813
  • ENST00000447872
  • ENSP00000401926
  • ENST00000610629
  • ENSP00000482197
  • ENSG00000274953
  • ENST00000610794
  • ENSP00000478582
  • ENSG00000276159
  • ENST00000610804
  • ENSP00000480533
  • ENSG00000274887
  • ENST00000611293
  • ENSP00000482555
  • ENSG00000275330
  • ENST00000612105
  • ENSP00000483412
  • ENSG00000275577
  • ENST00000612436
  • ENSP00000482985
  • ENSG00000276066
  • ENST00000612864
  • ENSP00000481977
  • ENSG00000275962
  • ENST00000613042
  • ENSP00000479748
  • ENST00000615235
  • ENSP00000479198
  • ENSG00000277607
  • ENST00000615508
  • ENSP00000484886
  • ENST00000616717
  • ENSP00000480383
  • ENST00000617115
  • ENSP00000481140
  • ENST00000617281
  • ENSP00000480547
  • ENST00000617776
  • ENSP00000484699
  • ENST00000617862
  • ENSP00000484844
  • ENSG00000276363
  • ENST00000619024
  • ENSP00000483411
  • ENST00000619921
  • ENSP00000483797
  • ENST00000620474
  • ENSP00000484806
  • ENST00000622762
  • ENSP00000483104

Symbol
  • SIRL1
  • SIRL-1
  • UNQ3033
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.56
tissue
0.54
protein domain
0.41
biological term
0.34
cellular component
0.33


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.02   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.02   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
GOLGA5
Tbio
Novelty:  0.04940885
p_int:  0.999902626
p_ni:  0.000097374
Data Source:  BioPlex
STEAP2
Tbio
Family:  Enzyme
Novelty:  0.02727622
p_int:  0.999757714
p_ni:  0.000021492
p_wrong:  0.000220794
Data Source:  BioPlex
OPA3
Tbio
Novelty:  0.01508376
p_int:  0.99953446
p_ni:  0.000085386
p_wrong:  0.000380154
Data Source:  BioPlex
XPR1
Tbio
Novelty:  0.00735578
p_int:  0.989420985
p_ni:  0.010578939
p_wrong:  7.7e-8
Data Source:  BioPlex
XPO7
Tbio
Novelty:  0.05412704
p_int:  0.9807671
p_ni:  0.0192329
Data Source:  BioPlex
SLC7A2
Tbio
Family:  Transporter
Novelty:  0.02262224
p_int:  0.97801787
p_ni:  0.020543775
p_wrong:  0.001438355
Data Source:  BioPlex
FADS1
Tchem
Family:  Enzyme
Novelty:  0.00160193
p_int:  0.977844969
p_ni:  0.020847349
p_wrong:  0.001307682
Data Source:  BioPlex
KIDINS220
Tbio
Family:  Enzyme
Novelty:  0.02169147
p_int:  0.960503895
p_ni:  0.039496105
Data Source:  BioPlex
CERS6
Tbio
Family:  TF
Novelty:  0.01956925
p_int:  0.930399759
p_ni:  0.06958921
p_wrong:  0.000011031
Data Source:  BioPlex
SLC7A3
Tbio
Family:  Transporter
Novelty:  0.00779949
p_int:  0.920661602
p_ni:  0.072763636
p_wrong:  0.006574762
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
66.8
viral load
1
1
1
66.8
viral load
1
1
1
66.8
viral load
1
1
1
66.8
viral load
1
1
1
66.8
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
66.8
viral load
1
66.8
viral load
1
66.8
viral load
1
66.8
viral load
1
66.8
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Dog
V-set and transmembrane domain containing 1
VGNC:54001
611492
Horse
V-set and transmembrane domain containing 1
VGNC:51098
100051802
Cow
V-set and transmembrane domain containing 1
618514
Species
Name
OMA
EggNOG
Inparanoid
Dog
V-set and transmembrane domain containing 1
Horse
V-set and transmembrane domain containing 1
Cow
V-set and transmembrane domain containing 1
Publication Statistics
PubMed Score 18.02
PubMed score by year
PubTator Score 13.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title