You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
VSNL1
Visinin-like protein 1

Protein Summary
Description
Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295156
  • ENSP00000295156
  • ENSG00000163032
  • ENST00000404666
  • ENSP00000384014
  • ENST00000406397
  • ENSP00000384719

Symbol
  • VISL1
  • HLP3
  • VILIP
  • HPCAL3
  • HUVISL1
  • VILIP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
virus perturbation
0.76
protein domain
0.73
interacting protein
0.72
transcription factor
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.7   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 1130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.7   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 1130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999999004
p_ni:  9.74e-7
p_wrong:  2.2e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999993485
p_ni:  0.000006512
p_wrong:  3e-9
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999988848
p_ni:  0.000011133
p_wrong:  1.9e-8
Data Source:  BioPlex
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.99997778
p_ni:  0.000022115
p_wrong:  1.05e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999946009
p_ni:  0.000053886
p_wrong:  1.05e-7
Data Source:  BioPlex
CDCA8
Tbio
Novelty:  0.01448513
p_int:  0.998497519
p_ni:  0.001281879
p_wrong:  0.000220602
Score:  0.158
Data Source:  BioPlex,STRINGDB
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
Score:  0.804
Data Source:  STRINGDB
KCND1
Tclin
Family:  IC
Novelty:  0.03738277
Score:  0.769
Data Source:  STRINGDB
KCND2
Tclin
Family:  IC
Novelty:  0.00297203
Score:  0.759
Data Source:  STRINGDB
UBLCP1
Tchem
Family:  Enzyme
Novelty:  0.14438023
Score:  0.701
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
54.4
mathematical ability
2
1
2
31.4
total cholesterol measurement
1
1
1
24.5
energy expenditure measurement
1
1
0
124
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
54.4
mathematical ability
2
31.4
total cholesterol measurement
1
24.5
energy expenditure measurement
0
124
17.8
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
visinin like 1
VGNC:1938
735653
Mouse
MGI:1349453
26950
Rat
RGD:3966
24877
Horse
visinin like 1
VGNC:24944
100056678
Cow
visinin like 1
VGNC:36841
282124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
visinin like 1
Mouse
Rat
Horse
visinin like 1
Cow
visinin like 1
Publication Statistics
PubMed Score 97.70
PubMed score by year
PubTator Score 69.93
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title