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Tbio
VSIG4
V-set and immunoglobulin domain-containing protein 4

Protein Summary
Description
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374737
  • ENSP00000363869
  • ENSG00000155659
  • ENST00000412866
  • ENSP00000394143
  • ENST00000455586
  • ENSP00000411581

Symbol
  • CRIg
  • Z39IG
  • CRIg
  • Z39IG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.75
protein domain
0.73
tissue sample
0.68
tissue
0.57
biological process
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.68   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.68   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (131)
INTS7
Tdark
Novelty:  0.04592325
p_int:  0.999291613
p_ni:  0.000708387
Data Source:  BioPlex
SH3BP4
Tbio
Novelty:  0.13130398
p_int:  0.997949574
p_ni:  0.001661805
p_wrong:  0.000388621
Data Source:  BioPlex
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
p_int:  0.993548722
p_ni:  0.006450762
p_wrong:  5.15e-7
Data Source:  BioPlex
SLC25A23
Tbio
Family:  Transporter
Novelty:  0.10446757
p_int:  0.989768833
p_ni:  0.010027393
p_wrong:  0.000203774
Data Source:  BioPlex
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.989710954
p_ni:  0.010286318
p_wrong:  0.000002728
Data Source:  BioPlex
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.987097695
p_ni:  0.00343083
p_wrong:  0.009471475
Data Source:  BioPlex
MTFP1
Tbio
Novelty:  0.01899273
p_int:  0.986161184
p_ni:  0.012526962
p_wrong:  0.001311854
Data Source:  BioPlex
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.963574495
p_ni:  0.036425505
Data Source:  BioPlex
PTCD2
Tdark
Novelty:  0.23529342
p_int:  0.962577644
p_ni:  0.037422356
Data Source:  BioPlex
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.955708526
p_ni:  0.044291474
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
72.2
1
2
2
70.5
platelet count
1
2
2
66.6
balding measurement
1
1
1
40.4
mean corpuscular volume
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
72.2
2
70.5
platelet count
2
66.6
balding measurement
1
40.4
mean corpuscular volume
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
V-set and immunoglobulin domain containing 4
VGNC:1182
465677
Macaque
V-set and immunoglobulin domain containing 4
709685
Mouse
MGI:2679720
278180
Rat
RGD:1564659
312102
Dog
V-set and immunoglobulin domain containing 4
VGNC:48308
491925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
V-set and immunoglobulin domain containing 4
Macaque
V-set and immunoglobulin domain containing 4
Mouse
Rat
Dog
V-set and immunoglobulin domain containing 4
Publication Statistics
PubMed Score 78.68
PubMed score by year
PubTator Score 28.83
PubTator score by year
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Related Publications
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PMID
Year
Title