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Tbio
VSIG1
V-set and immunoglobulin domain-containing protein 1

Protein Summary
Description
This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217957
  • ENSP00000217957
  • ENSG00000101842
  • ENST00000415430
  • ENSP00000402219

Symbol
  • GPA34
  • GPA34
  • dJ889N15.1
  • 1700062D20Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.52
gene perturbation
0.44
tissue sample
0.42
tissue
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.46   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
UBE4A
Tbio
Novelty:  0.02576018
p_int:  0.999999539
p_ni:  4.6e-7
p_wrong:  1e-9
Data Source:  BioPlex
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
p_int:  0.999999275
p_ni:  7.1e-7
p_wrong:  1.4e-8
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.999998744
p_ni:  0.000001256
Data Source:  BioPlex
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
p_int:  0.9999976
p_ni:  0.0000024
Data Source:  BioPlex
RRP1
Tbio
Novelty:  0.12984245
p_int:  0.999971217
p_ni:  0.000028783
Data Source:  BioPlex
SLC25A17
Tbio
Family:  Transporter
Novelty:  0.00601179
p_int:  0.999927969
p_ni:  0.000072031
Data Source:  BioPlex
DEPDC1
Tbio
Novelty:  0.04255829
p_int:  0.999810642
p_ni:  0.000183577
p_wrong:  0.000005781
Data Source:  BioPlex
CYP20A1
Tbio
Novelty:  0.11080329
p_int:  0.999715109
p_ni:  0.000284869
p_wrong:  2.3e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
EXOG
Tbio
Family:  Enzyme
Novelty:  0.03588463
p_int:  0.999418738
p_ni:  0.000580626
p_wrong:  6.36e-7
Data Source:  BioPlex
TTI1
Tbio
Novelty:  0.05516406
p_int:  0.999267484
p_ni:  0.000732516
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
V-set and immunoglobulin domain containing 1
VGNC:11600
465802
Macaque
V-set and immunoglobulin domain containing 1
703739
Mouse
MGI:1926039
78789
Rat
RGD:1565570
315920
Dog
V-set and immunoglobulin domain containing 1
VGNC:54610
481013
Species
Name
OMA
EggNOG
Inparanoid
Chimp
V-set and immunoglobulin domain containing 1
Macaque
V-set and immunoglobulin domain containing 1
Mouse
Rat
Dog
V-set and immunoglobulin domain containing 1
Publication Statistics
PubMed Score 10.46
PubMed score by year
PubTator Score 3.98
PubTator score by year
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Related Publications
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PMID
Year
Title