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Tbio
VPS51
Vacuolar protein sorting-associated protein 51 homolog

Protein Summary
Description
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN (PubMed:20685960). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061). This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279281
  • ENSP00000279281
  • ENSG00000149823

Symbol
  • ANG2
  • C11orf2
  • C11orf3
  • FFR
  • FFR
  • ANG2
  • ANG3
  • C11orf2
  • C11orf3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
drug perturbation
0.96
cell type or tissue
0.7
cellular component
0.64
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
GINS2
Tbio
Novelty:  0.0078966
p_int:  0.999977861
p_ni:  0.000022137
p_wrong:  1e-9
Data Source:  BioPlex
EIPR1
Tbio
Novelty:  0.08803081
p_int:  0.999915907
p_ni:  0.000084093
Score:  0.965
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.999512007
p_ni:  0.000487993
Score:  0.746
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999251037
p_ni:  0.000748963
Score:  0.394
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.996669826
p_ni:  0.003330174
Score:  0.663
Data Source:  BioPlex,STRINGDB
BSG
Tbio
Novelty:  0.0010285
p_int:  0.99280438
p_ni:  0.00719562
Score:  0.196
Data Source:  BioPlex,STRINGDB
VPS50
Tbio
Novelty:  0.17236696
p_int:  0.961664904
p_ni:  0.038335096
Score:  0.999
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.950358202
p_ni:  0.049641798
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.901024803
p_ni:  0.098975197
Data Source:  BioPlex
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.860817262
p_ni:  0.139182738
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
3
3
90.7
high density lipoprotein cholesterol measurement
1
1
1
48.5
1
1
0
1.9
13.9
platelet crit
1
1
1
13.1
metabolic syndrome
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
90.7
high density lipoprotein cholesterol measurement
1
48.5
0
1.9
13.9
platelet crit
1
13.1
metabolic syndrome
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS51, GARP complex subunit
VGNC:3039
451313
Macaque
VPS51, GARP complex subunit
716873
Mouse
MGI:1915755
68505
Rat
Dog
VPS51, GARP complex subunit
VGNC:48295
476028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS51, GARP complex subunit
Macaque
VPS51, GARP complex subunit
Mouse
Rat
Dog
VPS51, GARP complex subunit
Publication Statistics
PubMed Score 57.02
PubMed score by year
PubTator Score 84.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title