Pharos : Target Details

Tbio

Protein Summary

Description

Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).

Uniprot Accession IDs

Gene Name

VPS50

Ensembl ID

ENST00000251739
ENSP00000251739
ENSG00000004766
ENST00000305866
ENSP00000307666
ENST00000544910
ENSP00000443104

Symbol

CCDC132
KIAA1861
VPS54L
CCDC132

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0

biological term	0

cell line	0

cell type or tissue	0

cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 139 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.03 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 139 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

See Interactions on String-DB

VPS53

Tbio

Novelty: 0.07513165

p_int: 1

Score: 0.999

Data Source: BioPlex,STRINGDB

EIPR1

Tbio

Novelty: 0.08803081

p_int: 0.999999999

p_ni: 1e-9

Score: 0.949

Data Source: BioPlex,STRINGDB

GINS2

Tbio

Novelty: 0.0078966

p_int: 0.999999901

p_ni: 9.9e-8

Data Source: BioPlex

VPS54

Tbio

Novelty: 0.04428383

p_int: 0.999999497

p_ni: 5.02e-7

p_wrong: 1e-9

Score: 0.979

Data Source: BioPlex,STRINGDB

VPS52

Tbio

Novelty: 0.01439614

p_int: 0.99998195

p_ni: 0.00001805

Score: 0.997

Data Source: BioPlex,STRINGDB

SNAP29

Tbio

Novelty: 0.02009206

p_int: 0.999450479

p_ni: 0.000549521

Score: 0.822

Data Source: BioPlex,STRINGDB

DTNBP1

Tbio

Novelty: 0.00341619

p_int: 0.999410512

p_ni: 0.000589488

Score: 0.314

Data Source: BioPlex,STRINGDB

EXOC1

Tbio

Novelty: 0.01073858

p_int: 0.999152718

p_ni: 0.000847282

Score: 0.498

Data Source: BioPlex,STRINGDB

BSG

Tbio

Novelty: 0.0010285

p_int: 0.99849801

p_ni: 0.00150199

Score: 0.211

Data Source: BioPlex,STRINGDB

VPS51

Tbio

Novelty: 0.01766125

p_int: 0.961664904

p_ni: 0.038335096

Score: 0.999

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (1)

Components (5)

Processes (2)

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1 – 1 of 1

GO Term	Evidence	Assigned by
SNARE binding	Inferred from Direct Assay (IDA)	MGI

Disease Associations (null)

No disease associations found

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
body mass index	EFO_0004340	1	1	1	61.4

triglyceride measurement	EFO_0004530	1	1	2	35

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
body mass index	EFO_0004340	1	61.4

triglyceride measurement	EFO_0004530	2	35

Beta Count

Odds Ratio

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UniProt Keyword

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No Header	No Header
Acetylation

Alternative splicing

Coiled coil

Complete proteome

Endosome

Isopeptide bond

Phosphoprotein

Protein transport

Reference proteome

Transport

GWAS Trait

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IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID
Chimp	VPS50, EARP/GARPII complex subunit	VGNC:8788	463538

Macaque	VPS50, EARP/GARPII complex subunit		701991

Mouse	VPS50 EARP/GARPII complex subunit	MGI:1920538	73288

Rat	VPS50 EARP/GARPII complex subunit	RGD:1304751	312083

Dog	VPS50, EARP/GARPII complex subunit	VGNC:48294	475228

Species	Name	OMA	EggNOG	Inparanoid
Chimp	VPS50, EARP/GARPII complex subunit

Macaque	VPS50, EARP/GARPII complex subunit

Mouse	VPS50 EARP/GARPII complex subunit

Rat	VPS50 EARP/GARPII complex subunit

Dog	VPS50, EARP/GARPII complex subunit

Publication Statistics

PubMed Score 8.03

PubMed score by year

PubTator Score 1.87

PubTator score by year

Related Publications

Text Mined References (14)

GeneRif Annotations (2)

Items per page:

0 of 0

PMID	Year	Title