Protein Summary
Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).
- ENST00000251739
- ENSP00000251739
- ENSG00000004766
- ENST00000305866
- ENSP00000307666
- ENST00000544910
- ENSP00000443104
- CCDC132
- KIAA1861
- VPS54L
- CCDC132
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.03 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 139 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.03 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 139 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
EIPR1
Novelty: 0.08803081
p_int: 0.999999999
p_ni: 1e-9
Score: 0.949
Data Source: BioPlex,STRINGDB
VPS54
Novelty: 0.04428383
p_int: 0.999999497
p_ni: 5.02e-7
p_wrong: 1e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
VPS52
Novelty: 0.01439614
p_int: 0.99998195
p_ni: 0.00001805
Score: 0.997
Data Source: BioPlex,STRINGDB
SNAP29
Novelty: 0.02009206
p_int: 0.999450479
p_ni: 0.000549521
Score: 0.822
Data Source: BioPlex,STRINGDB
DTNBP1
Novelty: 0.00341619
p_int: 0.999410512
p_ni: 0.000589488
Score: 0.314
Data Source: BioPlex,STRINGDB
EXOC1
Novelty: 0.01073858
p_int: 0.999152718
p_ni: 0.000847282
Score: 0.498
Data Source: BioPlex,STRINGDB
BSG
Novelty: 0.0010285
p_int: 0.99849801
p_ni: 0.00150199
Score: 0.211
Data Source: BioPlex,STRINGDB
VPS51
Novelty: 0.01766125
p_int: 0.961664904
p_ni: 0.038335096
Score: 0.999
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 61.4 | |||||
triglyceride measurement | 1 | 1 | 2 | 35 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body mass index | 1 | 61.4 | |||||
triglyceride measurement | 2 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | VPS50, EARP/GARPII complex subunit | VGNC:8788 | 463538 | |||||
Macaque | VPS50, EARP/GARPII complex subunit | 701991 | ||||||
Mouse | MGI:1920538 | 73288 | ||||||
Rat | RGD:1304751 | 312083 | ||||||
Dog | VPS50, EARP/GARPII complex subunit | VGNC:48294 | 475228 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | VPS50, EARP/GARPII complex subunit | |||||
Macaque | VPS50, EARP/GARPII complex subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | VPS50, EARP/GARPII complex subunit | |||||
Publication Statistics
PubMed Score 8.03
PubMed score by year
PubTator Score 1.87
PubTator score by year
Related Publications
Text Mined References (14)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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