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Tbio
VPS4A
Vacuolar protein sorting-associated protein 4A

Protein Summary
Description
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis: retained at the midbody by ZFYVE19/ANCHR and CHMP4C until abscission checkpoint signaling is terminated at late cytokinesis. It is then released following dephosphory ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254950
  • ENSP00000254950
  • ENSG00000132612

Symbol
  • VPS4
  • SKD1
  • SKD2
  • VPS4
  • SKD1A
  • VPS4-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
molecular function
0.96
biological process
0.86
histone modification site profile
0.85
interacting protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.71   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.71   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
ZFYVE19
Tbio
Novelty:  0.32587685
p_int:  0.999999991
p_wrong:  9e-9
Score:  0.761
Data Source:  BioPlex,STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
p_int:  0.999998837
p_ni:  0.000001163
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
VTA1
Tbio
Novelty:  0.01697854
p_int:  0.826061018
p_ni:  0.173897874
p_wrong:  0.000041108
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
ARL8B
Tbio
Family:  Enzyme
Novelty:  0.06939851
p_int:  0.798036505
p_ni:  0.201778462
p_wrong:  0.000185033
Score:  0.238
Data Source:  BioPlex,STRINGDB
CHMP6
Tbio
Novelty:  0.02931
Score:  0.999
Data Source:  STRINGDB
CHMP1A
Tbio
Novelty:  0.03969333
Score:  0.999
Data Source:  STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.999
Data Source:  STRINGDB
CHMP2B
Tbio
Novelty:  0.01116381
Score:  0.995
Data Source:  STRINGDB
CHMP4B
Tbio
Novelty:  0.01391352
Score:  0.994
Data Source:  STRINGDB
CHMP1B
Tbio
Novelty:  0.06982523
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (202)
Budding and maturation of HIV virion (R-HSA-162588)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (57)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
2
4
80.6
daytime rest measurement
1
1
1
55.2
telomere length
1
1
1
38.8
apolipoprotein A 1 measurement
1
1
1
35
total cholesterol measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
80.6
daytime rest measurement
1
55.2
telomere length
1
38.8
apolipoprotein A 1 measurement
1
35
total cholesterol measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 4 homolog A
743569
Macaque
vacuolar protein sorting 4 homolog A
705277
Mouse
MGI:1890520
116733
Rat
RGD:628810
246772
Dog
vacuolar protein sorting 4 homolog A
479674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 4 homolog A
Macaque
vacuolar protein sorting 4 homolog A
Mouse
Rat
Dog
vacuolar protein sorting 4 homolog A
Publication Statistics
PubMed Score 68.71
PubMed score by year
PubTator Score 128.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title