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Tbio
VPS45
Vacuolar protein sorting-associated protein 45

Protein Summary
Description
May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369128
  • ENSP00000358124
  • ENSG00000136631
  • ENST00000369130
  • ENSP00000358126
  • ENST00000535106
  • ENSP00000440690
  • ENST00000644510
  • ENSP00000495563

Symbol
  • VPS45A
  • VPS45B
  • H1
  • SCN5
  • VSP45
  • VPS45A
  • VPS45B
  • VPS54A
  • VSP45A
  • H1VPS45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
interacting protein
0.85
transcription factor binding site profile
0.78
transcription factor
0.69
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.56   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.56   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0