Tbio VPS36 Vacuolar protein-sorting-associated protein 36

Protein Summary

Description

Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q86VN1
• A8K125
• Q3ZCV7
• Q5H9S1
• Q5VXB6
• Q9H8Z5
• Q9Y3E3

Gene Name

• VPS36

Ensembl ID

• ENST00000378060
• ENSP00000367299
• ENSG00000136100
• ENST00000611132
• ENSP00000484968

Symbol

• C13orf9
• EAP45
• EAP45
• C13orf9
• CGI-145

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
kinase perturbation	0.88
transcription factor binding site profile	0.82
cellular component	0.71
tissue sample	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.48   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.48   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0