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Tbio
VPS36
Vacuolar protein-sorting-associated protein 36

Protein Summary
Description
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A similar protein complex in rat is associated with RNA polymerase elongation factor II. [provided by RefSeq, A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378060
  • ENSP00000367299
  • ENSG00000136100
  • ENST00000611132
  • ENSP00000484968

Symbol
  • C13orf9
  • EAP45
  • EAP45
  • C13orf9
  • CGI-145
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.88
transcription factor binding site profile
0.82
cellular component
0.71
tissue sample
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
VPS25
Tbio
Novelty:  0.03002488
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SNF8
Tbio
Novelty:  0.04841708
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.999007885
p_ni:  0.000992115
Score:  0.991
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.9953707
p_ni:  0.001276252
p_wrong:  0.003353048
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.994907883
p_ni:  0.005065165
p_wrong:  0.000026952
Data Source:  BioPlex
KDELR1
Tbio
Novelty:  0.0036468
p_int:  0.993252316
p_ni:  0.002436212
p_wrong:  0.004311471
Score:  0.208
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.827351989
p_ni:  0.172647877
p_wrong:  1.34e-7
Score:  0.228
Data Source:  BioPlex,STRINGDB
CHMP6
Tbio
Novelty:  0.02931
Score:  0.998
Data Source:  STRINGDB
VPS28
Tbio
Novelty:  0.02927315
Score:  0.998
Data Source:  Reactome,STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.995
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Endosomal Sorting Complex Required For Transport (ESCRT) (R-HSA-917729)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Endosomal Sorting Complex Required For Transport (ESCRT)
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 36 homolog
VGNC:5132
452739
Macaque
vacuolar protein sorting 36 homolog
693290
Mouse
MGI:1917410
70160
Rat
RGD:1309754
290851
Dog
vacuolar protein sorting 36 homolog
VGNC:48286
477292
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vacuolar protein sorting 36 homolog
Macaque
vacuolar protein sorting 36 homolog
Mouse
Rat
Dog
vacuolar protein sorting 36 homolog
Publication Statistics
PubMed Score 33.95
PubMed score by year
PubTator Score 6.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title