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Tbio
VPS33B
Vacuolar protein sorting-associated protein 33B

Protein Summary
Description
May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity). Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333371
  • ENSP00000327650
  • ENSG00000184056
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.88
cellular component
0.84
histone modification site profile
0.79
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.88   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.88   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
CCDC22
Tbio
Novelty:  0.01400901
p_int:  0.999999974
p_ni:  2.2e-8
p_wrong:  4e-9
Score:  0.715
Data Source:  BioPlex,STRINGDB
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
p_int:  0.999999911
p_ni:  8.9e-8
Score:  0.266
Data Source:  BioPlex,STRINGDB
MATN4
Tdark
Novelty:  0.31964843
p_int:  0.999999864
p_ni:  1.34e-7
p_wrong:  2e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.99999892
p_ni:  0.000001076
p_wrong:  4e-9
Data Source:  BioPlex
KIF1B
Tbio
Novelty:  0.00984332
p_int:  0.999982445
p_ni:  0.000017554
Score:  0.223
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999877943
p_ni:  0.000122025
p_wrong:  3.2e-8
Data Source:  BioPlex
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.999773776
p_ni:  0.000226199
p_wrong:  2.5e-8
Data Source:  BioPlex
ITPRID2
Tbio
Novelty:  0.07923791
p_int:  0.999761234
p_ni:  0.000238761
p_wrong:  5e-9
Score:  0.526
Data Source:  BioPlex,STRINGDB
COMMD6
Tbio
Novelty:  0.11854363
p_int:  0.999107711
p_ni:  0.000878895
p_wrong:  0.000013394
Score:  0.787
Data Source:  BioPlex,STRINGDB
COMMD1
Tbio
Novelty:  0.01349432
p_int:  0.99837176
p_ni:  0.001604083
p_wrong:  0.000024157
Score:  0.622
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
6
7
99.5
9
5
4
1.1
95.1
mean platelet volume
3
2
3
93.3
1
1
0
33.3
79.4
1
1
0
100
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
99.5
4
1.1
95.1
mean platelet volume
3
93.3
0
33.3
79.4
0
100
77.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS33B, late endosome and lysosome associated
VGNC:8290
453657
Macaque
VPS33B, late endosome and lysosome associated
704144
Mouse
MGI:2446237
233405
Rat
RGD:620644
64060
Dog
VPS33B, late endosome and lysosome associated
VGNC:48284
479048
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS33B, late endosome and lysosome associated
Macaque
VPS33B, late endosome and lysosome associated
Mouse
Rat
Dog
VPS33B, late endosome and lysosome associated
Publication Statistics
PubMed Score 56.88
PubMed score by year
PubTator Score 32.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title