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Tbio
VPS28
Vacuolar protein sorting-associated protein 28 homolog

Protein Summary
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292510
  • ENSP00000292510
  • ENSG00000160948
  • ENST00000377348
  • ENSP00000366565
  • ENST00000526054
  • ENSP00000434064
  • ENST00000529182
  • ENSP00000434556
  • ENST00000642202
  • ENSP00000494521
  • ENSG00000285339
  • ENST00000642867
  • ENSP00000496519
  • ENST00000643186
  • ENSP00000496693
  • ENST00000646588
  • ENSP00000495408
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.97
virus perturbation
0.92
histone modification site profile
0.91
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.61   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.61   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
UBAP1
Tbio
Novelty:  0.02276845
p_int:  1
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
VPS37A
Tbio
Novelty:  0.09309134
p_int:  0.999999958
p_ni:  4.1e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
VPS37D
Tdark
Novelty:  1.44882563
p_int:  0.999999844
p_ni:  1.56e-7
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
MVB12A
Tbio
Novelty:  0.09794
p_int:  0.999999039
p_ni:  9.61e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
VPS37B
Tbio
Novelty:  0.22081527
p_int:  0.99999857
p_ni:  6.2e-8
p_wrong:  0.000001369
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MVB12B
Tbio
Novelty:  0.15964868
p_int:  0.999975278
p_ni:  0.000018769
p_wrong:  0.000005954
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
CYP2J2
Tchem
Novelty:  0.00534181
p_int:  0.999017469
p_ni:  0.000970666
p_wrong:  0.000011865
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.998640868
p_ni:  0.001359115
p_wrong:  1.7e-8
Data Source:  BioPlex
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.998150714
p_ni:  0.001849245
p_wrong:  4.1e-8
Score:  0.184
Data Source:  BioPlex,STRINGDB
SETX
Tbio
Family:  Enzyme
Novelty:  0.00474094
p_int:  0.996676063
p_ni:  0.003323936
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Autophagy
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8
94.2
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8
94.2
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS28, ESCRT-I subunit
VGNC:14614
464463
Macaque
VPS28, ESCRT-I subunit
702412
Mouse
MGI:1914164
66914
Rat
RGD:1306537
300052
Dog
VPS28, ESCRT-I subunit
VGNC:48282
607677
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS28, ESCRT-I subunit
Macaque
VPS28, ESCRT-I subunit
Mouse
Rat
Dog
VPS28, ESCRT-I subunit
Publication Statistics
PubMed Score 27.61
PubMed score by year
PubTator Score 12.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title