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Tdark
VPS26B
Vacuolar protein sorting-associated protein 26B

Protein Summary
Description
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281187
  • ENSP00000281187
  • ENSG00000151502
  • ENST00000525095
  • ENSP00000434162

Symbol
  • Pep8b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.81
co-expressed gene
0.69
transcription factor
0.62
transcription factor binding site profile
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
VPS29
Tbio
Novelty:  0.01335106
p_int:  1
Score:  0.998
Data Source:  BioPlex,STRINGDB
VPS26A
Tbio
Novelty:  0.01804654
p_int:  1
Score:  0.974
Data Source:  BioPlex,STRINGDB
TBC1D5
Tbio
Novelty:  0.11547525
p_int:  0.999999991
p_ni:  8e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
NEK1
Tchem
Family:  Kinase
Novelty:  0.0164923
p_int:  0.99999243
p_ni:  0.00000757
Score:  0.2
Data Source:  BioPlex,STRINGDB
VPS35
Tbio
Novelty:  0.00729892
p_int:  0.999988817
p_ni:  0.000011183
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999726147
p_ni:  0.000273853
Score:  0.74
Data Source:  BioPlex,STRINGDB
SNX3
Tbio
Novelty:  0.02703152
p_int:  0.998695067
p_ni:  0.001304933
Score:  0.944
Data Source:  BioPlex,STRINGDB
CFAP410
Tbio
Novelty:  0.0143773
p_int:  0.998471426
p_ni:  0.000396955
p_wrong:  0.001131619
Score:  0.2
Data Source:  BioPlex,STRINGDB
LRRC73
Tdark
Novelty:  48
p_int:  0.997787568
p_ni:  0.002212432
Data Source:  BioPlex
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.988671346
p_ni:  0.011328653
p_wrong:  1e-9
Score:  0.666
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carnitine measurement
1
1
0
9.2
76.1
blood protein measurement
2
2
2
68.8
educational attainment
1
2
2
53
brain measurement
1
1
0
7.3
47.2
neutrophil count
2
2
2
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
carnitine measurement
0
9.2
76.1
blood protein measurement
2
68.8
educational attainment
2
53
brain measurement
0
7.3
47.2
neutrophil count
2
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thymocyte nuclear protein 1
700413
Mouse
MGI:1917656
69091
Rat
RGD:1597170
300472
Dog
VPS26, retromer complex component B
VGNC:48281
607442
Horse
VPS26, retromer complex component B
VGNC:24919
100072880
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thymocyte nuclear protein 1
Mouse
Rat
Dog
VPS26, retromer complex component B
Horse
VPS26, retromer complex component B
Publication Statistics
PubMed Score 4.69
PubMed score by year
PubTator Score 2.23
PubTator score by year
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Related Publications
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PMID
Year
Title