You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
VPS13D
Vacuolar protein sorting-associated protein 13D

Protein Summary
Description
Functions in promoting mitochondrial clearance by mitochondrial autophagy (mitophagy), also possibly by positively regulating mitochondrial fission (PubMed:29307555). Mitophagy plays an important role in regulating cell health and mitochondrial size and homeostasis (PubMed:29307555). This gene encodes a protein belonging to the vacuolar-protein-sorting-13 gene family. In yeast, vacuolar-protein-sorting-13 proteins are involved in trafficking of membrane proteins between the trans-Golgi network and the prevacuolar compartment. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613099
  • ENSP00000482233
  • ENSG00000048707
  • ENST00000620676
  • ENSP00000478104

Symbol
  • KIAA0453
  • SCAR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
kinase perturbation
0.81
transcription factor binding site profile
0.77
virus perturbation
0.76
microRNA
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
TMEM31
Tdark
Novelty:  0.65381391
p_int:  0.999999975
p_ni:  2.5e-8
Data Source:  BioPlex
KIAA2013
Tdark
Novelty:  0.4705158
Score:  0.791
Data Source:  STRINGDB
IGSF21
Tdark
Novelty:  0.40656365
Score:  0.73
Data Source:  STRINGDB
EMC1
Tbio
Novelty:  0.05360812
Score:  0.72
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.66
Data Source:  STRINGDB
AKR7A3
Tbio
Family:  Enzyme
Novelty:  0.10681298
Score:  0.633
Data Source:  STRINGDB
AKR7A2
Tbio
Family:  Enzyme
Novelty:  0.00917827
Score:  0.629
Data Source:  STRINGDB
RALY
Tbio
Novelty:  0.03883322
Score:  0.614
Data Source:  STRINGDB
PARK7
Tbio
Family:  Enzyme
Novelty:  0.00104651
Score:  0.6
Data Source:  STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
Score:  0.59
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor II measurement
1
1
1
84.2
hematocrit
2
2
2
76.2
hemoglobin measurement
2
2
2
74.4
eosinophil count
1
1
1
69
eosinophil percentage of leukocytes
1
1
1
67.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tumor necrosis factor receptor II measurement
1
84.2
hematocrit
2
76.2
hemoglobin measurement
2
74.4
eosinophil count
1
69
eosinophil percentage of leukocytes
1
67.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2448530
230895
Rat
RGD:1308403
313825
Dog
vacuolar protein sorting 13 homolog D
VGNC:48277
478225
Horse
vacuolar protein sorting 13 homolog D
VGNC:24916
100050825
Opossum
vacuolar protein sorting 13 homolog D
100010145
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
vacuolar protein sorting 13 homolog D
Horse
vacuolar protein sorting 13 homolog D
Opossum
vacuolar protein sorting 13 homolog D
Publication Statistics
PubMed Score 15.07
PubMed score by year
PubTator Score 2.87
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title