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Tbio
VPS11
Vacuolar protein sorting-associated protein 11 homolog

Protein Summary
Description
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620429
  • ENSP00000479680
  • ENSG00000160695

Symbol
  • RNF108
  • END1
  • PEP5
  • HLD12
  • RNF108
  • hVPS11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
disease perturbation
0.87
kinase perturbation
0.81
histone modification site profile
0.77
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.41   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.41   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
VPS39
Tbio
Novelty:  0.02172601
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
TGFBRAP1
Tbio
Novelty:  0.05996919
p_int:  0.999999933
p_ni:  6.4e-8
p_wrong:  3e-9
Score:  0.996
Data Source:  BioPlex,STRINGDB
VPS41
Tbio
Novelty:  0.08480171
p_int:  0.999997882
p_ni:  0.000002118
Score:  0.999
Data Source:  BioPlex,STRINGDB
VPS18
Tbio
Novelty:  0.00726539
p_int:  0.999953881
p_ni:  0.000046119
Score:  0.999
Data Source:  BioPlex,STRINGDB
LRRC61
Tdark
Novelty:  1.45343096
p_int:  0.999408695
p_ni:  0.000591238
p_wrong:  6.7e-8
Data Source:  BioPlex
TMEM266
Tdark
Novelty:  0.26313861
p_int:  0.999380288
p_ni:  0.000619712
Score:  0.795
Data Source:  BioPlex,STRINGDB
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999096936
p_ni:  0.000903064
Data Source:  BioPlex
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.997692676
p_ni:  0.002307324
Data Source:  BioPlex
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.996121489
p_ni:  0.00387851
p_wrong:  1e-9
Data Source:  BioPlex
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.985724539
p_ni:  0.014275461
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (59)
Find Similar Targets
Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Ebola Virus Pathway on Host
Name
Explore in Pharos
Explore in Source
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Ebola Virus Pathway on Host
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
21
4
21
89.4
mean reticulocyte volume
1
2
2
86
body mass index
4
4
4
84
serum albumin measurement
2
3
3
82.4
calcium measurement
2
2
2
80
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
21
89.4
mean reticulocyte volume
2
86
body mass index
4
84
serum albumin measurement
3
82.4
calcium measurement
2
80
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
VPS11, CORVET/HOPS core subunit
702834
Mouse
MGI:1918982
71732
Rat
RGD:1308038
315600
Dog
VPS11, CORVET/HOPS core subunit
VGNC:48273
489374
Horse
VPS11, CORVET/HOPS core subunit
VGNC:24913
100063269
Species
Name
OMA
EggNOG
Inparanoid
Macaque
VPS11, CORVET/HOPS core subunit
Mouse
Rat
Dog
VPS11, CORVET/HOPS core subunit
Horse
VPS11, CORVET/HOPS core subunit
Publication Statistics
PubMed Score 182.41
PubMed score by year
PubTator Score 71.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title