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Tbio
VNN3
Vascular non-inflammatory molecule 3

Protein Summary
Description
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275223
  • ENSP00000443073
  • ENSG00000093134
  • ENST00000367927
  • ENSP00000438024
  • ENST00000392393
  • ENSP00000441182
  • ENST00000414302
  • ENSP00000444505
  • ENST00000417437
  • ENSP00000463583
  • ENST00000423615
  • ENSP00000443901
  • ENST00000425515
  • ENSP00000439449
  • ENST00000427187
  • ENSP00000444491
  • ENST00000509351
  • ENSP00000464241
  • ENST00000519686
  • ENSP00000438175

Symbol
  • HSA238982
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
tissue sample
0.76
cell line
0.61
virus perturbation
0.55
metabolite
0.45


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.37   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.37   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
p_int:  0.999905144
p_wrong:  0.000094856
Score:  0.91
Data Source:  BioPlex,STRINGDB
CEACAM7
Tbio
Novelty:  0.05266788
Score:  0.916
Data Source:  STRINGDB
VNN2
Tbio
Novelty:  0.02286648
Score:  0.914
Data Source:  STRINGDB
TEX101
Tbio
Novelty:  0.03488625
Score:  0.908
Data Source:  STRINGDB
PRSS21
Tbio
Family:  Enzyme
Novelty:  0.0110251
Score:  0.906
Data Source:  STRINGDB
FCGR3B
Tbio
Novelty:  0.000429
Score:  0.906
Data Source:  STRINGDB
CD109
Tbio
Novelty:  0.01280272
Score:  0.905
Data Source:  STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
Score:  0.905
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.904
Data Source:  STRINGDB
RTN4RL1
Tbio
Novelty:  0.07113722
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 9.37
PubMed score by year
PubTator Score 3.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title