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Tdark
VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339485
  • ENSP00000343348
  • ENSG00000187650
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.7
histone modification site profile
0.67
transcription factor binding site profile
0.66
tissue sample
0.62
tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
BANP
Tbio
Novelty:  0.02145545
p_int:  0.999985686
p_ni:  0.00001431
p_wrong:  4e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
RPL22L1
Tdark
Novelty:  0.19211417
p_int:  0.999707272
p_ni:  0.000292716
p_wrong:  1.2e-8
Score:  0.379
Data Source:  BioPlex,STRINGDB
SMR3A
Tbio
Novelty:  0.05160207
p_int:  0.999205231
p_ni:  0.000794769
Score:  0.537
Data Source:  BioPlex,STRINGDB
ESS2
Tbio
Novelty:  0.00163665
Score:  0.586
Data Source:  STRINGDB
C8orf37
Tbio
Novelty:  0.06339955
Score:  0.529
Data Source:  STRINGDB
SDK2
Tdark
Novelty:  0.08867136
Score:  0.513
Data Source:  STRINGDB
NPPC
Tbio
Novelty:  0.00114199
Score:  0.498
Data Source:  STRINGDB
NPR3
Tchem
Novelty:  0.00227442
Score:  0.492
Data Source:  STRINGDB
NPR1
Tclin
Family:  Kinase
Novelty:  0.00170829
Score:  0.492
Data Source:  STRINGDB
NPR2
Tclin
Family:  Kinase
Novelty:  0.00418989
Score:  0.481
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
4
4
8
99.1
cancer biomarker measurement
1
3
4
98.5
vitamin B12 measurement
2
3
2
49.8
96.4
N-glycan measurement
2
1
18
93.4
cancer antigen 19.9 measurement
1
2
2
92.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
8
99.1
cancer biomarker measurement
4
98.5
vitamin B12 measurement
2
49.8
96.4
N-glycan measurement
18
93.4
cancer antigen 19.9 measurement
2
92.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vimentin type intermediate filament associated coiled-coil protein
455629
Mouse
MGI:2146912
106639
Rat
RGD:1303340
363327
Dog
vimentin type intermediate filament associated coiled-coil protein
100856024
Cow
vimentin type intermediate filament associated coiled-coil protein
515212
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vimentin type intermediate filament associated coiled-coil protein
Mouse
Rat
Dog
vimentin type intermediate filament associated coiled-coil protein
Cow
vimentin type intermediate filament associated coiled-coil protein
Publication Statistics
PubMed Score 3.17
PubMed score by year
PubTator Score 11.50
PubTator score by year
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Related Publications
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PMID
Year
Title