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Tdark
VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

Protein Summary
Description
Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase.[provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330374
  • ENSP00000333255
  • ENSG00000160131
  • ENST00000370361
  • ENSP00000359386

Symbol
  • MEAX
  • XMEA
  • MEAX
  • XMEA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.88
microRNA
0.75
cellular component
0.73
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.05   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.05   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
ATP6AP2
Tbio
Novelty:  0.00357665
p_int:  0.99999589
p_ni:  0.000004106
p_wrong:  4e-9
Score:  0.901
Data Source:  BioPlex,STRINGDB
CMTM8
Tbio
Novelty:  0.0953768
p_int:  0.999994578
p_ni:  0.000004736
p_wrong:  6.86e-7
Data Source:  BioPlex
KIAA2013
Tdark
Novelty:  0.4705158
p_int:  0.999990941
p_ni:  0.000006715
p_wrong:  0.000002344
Score:  0.851
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.999936914
p_ni:  0.000063083
p_wrong:  2e-9
Score:  0.765
Data Source:  BioPlex,STRINGDB
ATP6V0D2
Tbio
Family:  Enzyme
Novelty:  0.0354396
p_int:  0.999932317
p_ni:  0.000065671
p_wrong:  0.000002012
Score:  0.883
Data Source:  BioPlex,STRINGDB
TMEM199
Tbio
Novelty:  0.05799147
p_int:  0.999893716
p_ni:  0.000103901
p_wrong:  0.000002383
Score:  0.935
Data Source:  BioPlex,STRINGDB
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.999805051
p_ni:  0.000194949
Score:  0.753
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999606268
p_ni:  0.000237155
p_wrong:  0.000156577
Data Source:  BioPlex
ECSCR
Tbio
Novelty:  0.11603718
p_int:  0.999413497
p_ni:  0.000586455
p_wrong:  4.7e-8
Data Source:  BioPlex
METTL9
Tdark
Family:  Enzyme
Novelty:  0.20589257
p_int:  0.998438022
p_ni:  0.001547967
p_wrong:  0.000014011
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
9.9
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914298
67048
Dog
VMA21, vacuolar ATPase assembly factor
VGNC:48270
481074
Cow
VMA21, vacuolar ATPase assembly factor
VGNC:36804
613674
Opossum
VMA21, vacuolar ATPase assembly factor
100025962
Platypus
VMA21, vacuolar ATPase assembly factor
100081365
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
VMA21, vacuolar ATPase assembly factor
Cow
VMA21, vacuolar ATPase assembly factor
Opossum
VMA21, vacuolar ATPase assembly factor
Platypus
VMA21, vacuolar ATPase assembly factor
Publication Statistics
PubMed Score 2.05
PubMed score by year
PubTator Score 19.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title