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Tchem
VIPR1
Vasoactive intestinal polypeptide receptor 1

Protein Summary
Description
This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325123
  • ENSP00000327246
  • ENSG00000114812
  • ENST00000433647
  • ENSP00000394950
  • ENST00000438259
  • ENSP00000415371
  • ENST00000543411
  • ENSP00000445701

Symbol
  • II
  • HVR1
  • RDC1
  • V1RG
  • VIPR
  • VIRG
  • VAPC1
  • VPAC1
  • VPAC1R
  • VIP-R-1
  • VPCAP1R
  • PACAP-R2
  • PACAP-R-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
0.85
protein domain
0.85
PubMedID
0.65
gene perturbation
0.63
small molecule perturbation
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 584.67   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 584.67   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (191)
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.997766529
p_ni:  0.002232919
p_wrong:  5.52e-7
Score:  0.153
Data Source:  BioPlex,STRINGDB
SC5D
Tbio
Family:  Enzyme
Novelty:  0.02446366
p_int:  0.99649332
p_ni:  0.00326574
p_wrong:  0.00024094
Score:  0.522
Data Source:  BioPlex,STRINGDB
ARFGEF3
Tdark
Novelty:  0.20402365
p_int:  0.993853883
p_ni:  0.006146111
p_wrong:  6e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
XPO6
Tbio
Novelty:  0.03229708
p_int:  0.979206428
p_ni:  0.020793571
p_wrong:  1e-9
Data Source:  BioPlex
MFSD5
Tdark
Novelty:  0.58146966
p_int:  0.974298478
p_ni:  0.025170488
p_wrong:  0.000531033
Score:  0.207
Data Source:  BioPlex,STRINGDB
RNF13
Tbio
Family:  Enzyme
Novelty:  0.09764564
p_int:  0.969129793
p_ni:  0.030870194
p_wrong:  1.3e-8
Data Source:  BioPlex
DYM
Tbio
Novelty:  0.02348265
p_int:  0.959286193
p_ni:  0.040713803
p_wrong:  4e-9
Data Source:  BioPlex
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.944211237
p_ni:  0.055788763
Data Source:  BioPlex
GPR89A
Tbio
Family:  IC
Novelty:  0.06782776
p_int:  0.941037789
p_ni:  0.058962185
p_wrong:  2.6e-8
Data Source:  BioPlex
HACD2
Tbio
Family:  Enzyme
Novelty:  0.16943742
p_int:  0.929356014
p_ni:  0.070642037
p_wrong:  0.000001949
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eotaxin measurement
1
1
1
70.2
body height
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eotaxin measurement
1
70.2
body height
1
6.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
vasoactive intestinal peptide receptor 1
717438
Mouse
MGI:109272
22354
Dog
vasoactive intestinal peptide receptor 1
VGNC:48265
477035
Horse
vasoactive intestinal peptide receptor 1
VGNC:24908
100055146
Cow
vasoactive intestinal peptide receptor 1
VGNC:36799
535858
Species
Name
OMA
EggNOG
Inparanoid
Macaque
vasoactive intestinal peptide receptor 1
Mouse
Dog
vasoactive intestinal peptide receptor 1
Horse
vasoactive intestinal peptide receptor 1
Cow
vasoactive intestinal peptide receptor 1
Publication Statistics
PubMed Score 584.67
PubMed score by year
PubTator Score 323.93
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title