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Tbio
VIPAS39
Spermatogenesis-defective protein 39 homolog

Protein Summary
Description
Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity). This gene encodes a protein involved in the sorting of lysosomal proteins. Mutations in this gene are associated with ARCS2 (arthrogryposis, renal dysfunction, and cholestasis-2). Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327028
  • ENSP00000313098
  • ENSG00000151445
  • ENST00000343765
  • ENSP00000339122
  • ENST00000448935
  • ENSP00000404815
  • ENST00000553888
  • ENSP00000452181
  • ENST00000557658
  • ENSP00000452191

Symbol
  • C14orf133
  • SPE39
  • VIPAR
  • SPE39
  • VIPAR
  • SPE-39
  • VPS16B
  • hSPE-39
  • C14orf133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
interacting protein
0.86
transcription factor binding site profile
0.86
histone modification site profile
0.81
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.63   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.63   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
p_int:  0.999999949
p_ni:  5.1e-8
Score:  0.346
Data Source:  BioPlex,STRINGDB
MATN4
Tdark
Novelty:  0.31964843
p_int:  0.999999893
p_ni:  1.05e-7
p_wrong:  2e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
CCDC22
Tbio
Novelty:  0.01400901
p_int:  0.999998229
p_ni:  2.5e-8
p_wrong:  0.000001746
Score:  0.377
Data Source:  BioPlex,STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.999995683
p_ni:  0.0000043
p_wrong:  1.7e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
KIF1B
Tbio
Novelty:  0.00984332
p_int:  0.999963163
p_ni:  0.000036714
p_wrong:  1.22e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
LYG2
Tbio
Family:  Enzyme
Novelty:  0.12091256
p_int:  0.999441262
p_ni:  0.000210236
p_wrong:  0.000348503
Score:  0.169
Data Source:  BioPlex,STRINGDB
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.986329456
p_ni:  0.008989179
p_wrong:  0.004681365
Data Source:  BioPlex
VPS33B
Tbio
Novelty:  0.02221093
Score:  0.997
Data Source:  STRINGDB
VPS33A
Tbio
Novelty:  0.08316241
Score:  0.962
Data Source:  STRINGDB
VPS16
Tbio
Novelty:  0.03575558
Score:  0.851
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
85
myeloid white cell count
2
2
2
74.7
leukocyte count
2
2
2
67.5
granulocyte count
1
1
1
54.4
sum of neutrophil and eosinophil counts
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
85
myeloid white cell count
2
74.7
leukocyte count
2
67.5
granulocyte count
1
54.4
sum of neutrophil and eosinophil counts
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
453069
Macaque
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
706315
Mouse
MGI:2144805
104799
Rat
RGD:1589291
681989
Dog
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VGNC:48264
490808
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Macaque
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Mouse
Rat
Dog
VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
Publication Statistics
PubMed Score 43.63
PubMed score by year
PubTator Score 19.57
PubTator score by year
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Related Publications
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PMID
Year
Title