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Tbio
VIP
VIP peptides

Protein Summary
Description
VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin. The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367243
  • ENSP00000356212
  • ENSG00000146469
  • ENST00000367244
  • ENSP00000356213

Symbol
  • PHM27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
biological term
0.85
disease
0.7
cell type or tissue
0.66
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4658.26   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 469   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4658.26   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (237)
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.985747747
p_ni:  0.014252253
Data Source:  BioPlex
PXDN
Tbio
Novelty:  0.00935722
p_int:  0.923807819
p_ni:  0.076192181
Score:  0.187
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.889902798
p_ni:  0.110096986
p_wrong:  2.16e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.881799345
p_ni:  0.118200655
Score:  0.205
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
Score:  0.997
Data Source:  Reactome,STRINGDB
VIPR1
Tchem
Family:  GPCR
Novelty:  0.0016529
Score:  0.997
Data Source:  Reactome,STRINGDB
SCT
Tbio
Novelty:  0.00070278
Score:  0.989
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.988
Data Source:  STRINGDB
P01258
Tbio
Novelty:  0.00010496
Score:  0.987
Data Source:  STRINGDB
P06881
Tclin
Novelty:  0.00010496
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (207)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
2
1.2
90.7
serum gamma-glutamyl transferase measurement
1
1
1
74.5
myeloid white cell count
1
1
1
72.3
lymphocyte count
2
1
2
68
leukocyte count
1
1
1
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.2
90.7
serum gamma-glutamyl transferase measurement
1
74.5
myeloid white cell count
1
72.3
lymphocyte count
2
68
leukocyte count
1
65.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vasoactive intestinal peptide
VGNC:3785
472164
Macaque
vasoactive intestinal peptide
703566
Mouse
MGI:98933
22353
Rat
RGD:621647
117064
Dog
vasoactive intestinal peptide
VGNC:54000
484038
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vasoactive intestinal peptide
Macaque
vasoactive intestinal peptide
Mouse
Rat
Dog
vasoactive intestinal peptide
Publication Statistics
PubMed Score 4658.26
PubMed score by year
PubTator Score 4069.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title