Protein Summary
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients. [provided by Ref ...more
- ENST00000224237
- ENSP00000224237
- ENSG00000026025
- ENST00000544301
- ENSP00000446007
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
kinase | 1 | ||
protein complex | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3520.2 (req: < 5)
Gene RIFs: 325 (req: <= 3)
Antibodies: 3179 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3520.2 (req: >= 5)
Gene RIFs: 325 (req: > 3)
Antibodies: 3179 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (244)
NEFM
Novelty: 0.00239134
p_int: 0.999999746
p_ni: 2.54e-7
Score: 0.83
Data Source: BioPlex,STRINGDB
DES
Novelty: 0.00651741
p_int: 0.999999562
p_ni: 2e-9
p_wrong: 4.36e-7
Score: 0.987
Data Source: BioPlex,STRINGDB
NES
Novelty: 0.00035379
p_int: 0.999998286
p_ni: 0.00000171
p_wrong: 4e-9
Score: 0.864
Data Source: BioPlex,STRINGDB
INA
Novelty: 0.00708581
p_int: 0.999996709
p_ni: 0.000003291
Score: 0.817
Data Source: BioPlex,STRINGDB
NEFL
Novelty: 0.00049255
p_int: 0.999969372
p_ni: 0.000030628
Score: 0.694
Data Source: BioPlex,STRINGDB
GFAP
Novelty: 0.00020932
p_int: 0.999935914
p_ni: 0.000064086
Score: 0.819
Data Source: BioPlex,Reactome,STRINGDB
GAN
Novelty: 0.01069743
p_int: 0.998092133
p_ni: 0.001907867
Score: 0.906
Data Source: BioPlex,STRINGDB
SYNC
Novelty: 0.04605223
p_int: 0.993061397
p_ni: 0.006938603
Score: 0.779
Data Source: BioPlex,STRINGDB
RSPRY1
Novelty: 0.26883105
p_int: 0.990370232
p_ni: 0.009629768
Score: 0.621
Data Source: BioPlex,STRINGDB
PRMT8
Family: Epigenetic
Novelty: 0.04213384
p_int: 0.949033937
p_ni: 0.050966063
Score: 0.324
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (26)
Reactome (11)
KEGG (2)
PathwayCommons (4)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Caspase-mediated cleavage of cytoskeletal proteins | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Caspase-mediated cleavage of cytoskeletal proteins | ||||
Cytokine Signaling in Immune system | ||||
Viral Interactions (0)
Gene Ontology Terms (37)
Functions (8)
Components (14)
Processes (15)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
total cholesterol measurement | 3 | 2 | 3 | 78.7 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 9.4 | 73.7 | ||||
low density lipoprotein cholesterol measurement | 2 | 2 | 2 | 62 | |||||
mean corpuscular volume | 1 | 1 | 1 | 59.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 46.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
total cholesterol measurement | 3 | 78.7 | |||||
aspartate aminotransferase measurement | 0 | 9.4 | 73.7 | ||||
low density lipoprotein cholesterol measurement | 2 | 62 | |||||
mean corpuscular volume | 1 | 59.6 | |||||
high density lipoprotein cholesterol measurement | 1 | 46.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | vimentin | VGNC:5877 | 493952 | |||||
Macaque | vimentin | 705289 | ||||||
Mouse | MGI:98932 | 22352 | ||||||
Rat | RGD:621646 | 81818 | ||||||
Dog | vimentin | VGNC:48263 | 477991 | |||||
Publication Statistics
PubMed Score 3520.20
PubMed score by year
PubTator Score 8543.76
PubTator score by year
Related Publications
Text Mined References (419)
GeneRif Annotations (325)
Items per page:
0 of 0
PMID | Year | Title |
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