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Tbio
VGF
Neurosecretory protein VGF

Protein Summary
Description
May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release. Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris. This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249330
  • ENSP00000249330
  • ENSG00000128564
  • ENST00000445482
  • ENSP00000400884

Symbol
  • SCG7
  • SgVII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.81
transcription factor binding site profile
0.74
cell type or tissue
0.72
phenotype
0.72
gene perturbation
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.59   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 269.59   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
SCG3
Tbio
Novelty:  0.02153066
Score:  0.973
Data Source:  STRINGDB
SCG2
Tbio
Novelty:  0.00389492
Score:  0.97
Data Source:  STRINGDB
CHGB
Tbio
Novelty:  0.00484507
Score:  0.968
Data Source:  STRINGDB
CST3
Tbio
Novelty:  0.00021856
Score:  0.948
Data Source:  STRINGDB
PENK
Tbio
Novelty:  0.00074167
Score:  0.94
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.925
Data Source:  STRINGDB
APP
Tclin
Novelty:  0.00008964
Score:  0.918
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.913
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.911
Data Source:  STRINGDB
MBTPS1
Tchem
Family:  Enzyme
Novelty:  0.00845881
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
1
1
71.9
plasminogen activator inhibitor 1 measurement
1
1
1
62.8
blood protein measurement
2
2
2
56.9
body mass index
2
2
2
46.9
lymphocyte count
1
1
1
42.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metabolite measurement
1
71.9
plasminogen activator inhibitor 1 measurement
1
62.8
blood protein measurement
2
56.9
body mass index
2
46.9
lymphocyte count
1
42.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
VGF nerve growth factor inducible
719578
Mouse
MGI:1343180
381677
Rat
RGD:69399
29461
Dog
VGF nerve growth factor inducible
VGNC:54090
100687924
Cow
VGF nerve growth factor inducible
VGNC:36790
618042
Species
Name
OMA
EggNOG
Inparanoid
Macaque
VGF nerve growth factor inducible
Mouse
Rat
Dog
VGF nerve growth factor inducible
Cow
VGF nerve growth factor inducible
Publication Statistics
PubMed Score 269.59
PubMed score by year
PubTator Score 82.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title