Tbio VEZT Vezatin

Protein Summary

Description

Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q9HBM0
• Q6P1Q3
• Q9H2F4
• Q9H2U5
• Q9NT70
• Q9NVW0
• Q9UF91

Gene Name

• VEZT

Ensembl ID

• ENST00000436874
• ENSP00000410083
• ENSG00000028203
• ENST00000546557
• ENSP00000447080
• ENST00000547484
• ENSP00000447010
• ENST00000547997
• ENSP00000449346
• ENST00000548455
• ENSP00000447044
• ENST00000549624
• ENSP00000448555
• ENST00000550803
• ENSP00000449056
• ENST00000552660
• ENSP00000447786

Symbol

• VEZATIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
virus perturbation	0.79
small molecule perturbation	0.75
kinase perturbation	0.71
microRNA	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.67   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.67   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0