Tbio VEZT Vezatin

Protein Summary

Description

Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q9HBM0
• Q6P1Q3
• Q9H2F4
• Q9H2U5
• Q9NT70
• Q9NVW0
• Q9UF91

Gene Name

• VEZT

Ensembl ID

• ENST00000436874
• ENSP00000410083
• ENSG00000028203
• ENST00000546557
• ENSP00000447080
• ENST00000547484
• ENSP00000447010
• ENST00000547997
• ENSP00000449346
• ENST00000548455
• ENSP00000447044
• ENST00000549624
• ENSP00000448555
• ENST00000550803
• ENSP00000449056
• ENST00000552660
• ENSP00000447786

Symbol

• VEZATIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
virus perturbation	0.79
small molecule perturbation	0.75
kinase perturbation	0.71
microRNA	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.18   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.18   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

VIPR2

Tchem

Family:  GPCR

Novelty:  0.00463802

p_int:  0.999970869

p_ni:  0.000029131

Data Source:  BioPlex

C11orf87

Tdark

Novelty:  1.33249342

p_int:  0.999819466

p_ni:  0.00005104

p_wrong:  0.000129494

Data Source:  BioPlex

C3AR1

Tchem

Family:  GPCR

Novelty:  0.00527301

p_int:  0.99966512

p_ni:  0.000334875

p_wrong:  4e-9

Data Source:  BioPlex

TMED6

Tdark

Novelty:  0.598611

p_int:  0.997033216

p_ni:  0.00286461

p_wrong:  0.000102174

Data Source:  BioPlex

GPR21

Tdark

Family:  GPCR

Novelty:  0.90865557

p_int:  0.995022721

p_ni:  0.004934604

p_wrong:  0.000042676

Data Source:  BioPlex

FZD10

Tbio

Family:  GPCR

Novelty:  0.02786933

p_int:  0.994386569

p_ni:  0.00555189

p_wrong:  0.000061541

Data Source:  BioPlex

DLK2

Tbio

Novelty:  0.06366405

p_int:  0.99412136

p_ni:  0.005796337

p_wrong:  0.000082303

Data Source:  BioPlex

PLEKHO2

Tdark

Novelty:  0.48296621

p_int:  0.973192148

p_ni:  0.018949327

p_wrong:  0.007858524

Score:  0.28

Data Source:  BioPlex,STRINGDB

PCDHGB2

Tdark

Novelty:  1.16587709

p_int:  0.967568663

p_ni:  0.032407886

p_wrong:  0.00002345

Data Source:  BioPlex

CHRM4

Tclin

Family:  GPCR

Novelty:  0.00759817

p_int:  0.934630815

p_ni:  0.003564611

p_wrong:  0.061804575

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (1)

Components (7)

Processes (1)

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GO Term	Evidence	Assigned by
myosin binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1	1	0	1.1	83
FEV/FEC ratio	EFO_0004713	1	1	1		73.9
endometriosis	EFO_0001065	2	2	0	1.1	59
platelet count	EFO_0004309	1	1	1		46.9
chronic obstructive pulmonary disease	EFO_0000341	1	1	0	1.1	21.5

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	0	1.1	83
FEV/FEC ratio	EFO_0004713	1		73.9
endometriosis	EFO_0001065	0	1.1	59
platelet count	EFO_0004309	1		46.9
chronic obstructive pulmonary disease	EFO_0000341	0	1.1	21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell junction
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasmic vesicle
Membrane
Nucleus
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
chronic obstructive pulmonary disease
chronotype measurement
endometriosis
FEV/FEC ratio
high density lipoprotein cholesterol measurement
platelet count
sleep duration
wet macular degeneration

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
embryo phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	vezatin, adherens junctions transmembrane protein	VGNC:8590	452138
Macaque	vezatin, adherens junctions transmembrane protein		716675
Mouse	vezatin, adherens junctions transmembrane protein	MGI:2143698	215008
Rat	vezatin, adherens junctions transmembrane protein	RGD:1359117	299738
Dog	vezatin, adherens junctions transmembrane protein	VGNC:49719	111090044

Species	Name	OMA	EggNOG	Inparanoid
Chimp	vezatin, adherens junctions transmembrane protein
Macaque	vezatin, adherens junctions transmembrane protein
Mouse	vezatin, adherens junctions transmembrane protein
Rat	vezatin, adherens junctions transmembrane protein
Dog	vezatin, adherens junctions transmembrane protein

Publication Statistics

PubMed Score 20.18

PubMed score by year

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PubTator Score 8.91

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (7)

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PMID	Year	Title