Protein Summary
Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
- ENST00000436874
- ENSP00000410083
- ENSG00000028203
- ENST00000546557
- ENSP00000447080
- ENST00000547484
- ENSP00000447010
- ENST00000547997
- ENSP00000449346
- ENST00000548455
- ENSP00000447044
- ENST00000549624
- ENSP00000448555
- ENST00000550803
- ENSP00000449056
- ENST00000552660
- ENSP00000447786
- VEZATIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.88 | ||
virus perturbation | 0.79 | ||
small molecule perturbation | 0.75 | ||
kinase perturbation | 0.71 | ||
microRNA | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.18 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 57 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.18 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 57 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (68)
VIPR2
Family: GPCR
Novelty: 0.00463802
p_int: 0.999970869
p_ni: 0.000029131
Data Source: BioPlex
C11orf87
Novelty: 1.33249342
p_int: 0.999819466
p_ni: 0.00005104
p_wrong: 0.000129494
Data Source: BioPlex
C3AR1
Family: GPCR
Novelty: 0.00527301
p_int: 0.99966512
p_ni: 0.000334875
p_wrong: 4e-9
Data Source: BioPlex
TMED6
Novelty: 0.598611
p_int: 0.997033216
p_ni: 0.00286461
p_wrong: 0.000102174
Data Source: BioPlex
GPR21
Family: GPCR
Novelty: 0.90865557
p_int: 0.995022721
p_ni: 0.004934604
p_wrong: 0.000042676
Data Source: BioPlex
FZD10
Family: GPCR
Novelty: 0.02786933
p_int: 0.994386569
p_ni: 0.00555189
p_wrong: 0.000061541
Data Source: BioPlex
DLK2
Novelty: 0.06366405
p_int: 0.99412136
p_ni: 0.005796337
p_wrong: 0.000082303
Data Source: BioPlex
PLEKHO2
Novelty: 0.48296621
p_int: 0.973192148
p_ni: 0.018949327
p_wrong: 0.007858524
Score: 0.28
Data Source: BioPlex,STRINGDB
PCDHGB2
Novelty: 1.16587709
p_int: 0.967568663
p_ni: 0.032407886
p_wrong: 0.00002345
Data Source: BioPlex
CHRM4
Family: GPCR
Novelty: 0.00759817
p_int: 0.934630815
p_ni: 0.003564611
p_wrong: 0.061804575
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (7)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 1 | 0 | 1.1 | 83 | ||||
FEV/FEC ratio | 1 | 1 | 1 | 73.9 | |||||
2 | 2 | 0 | 1.1 | 59 | |||||
platelet count | 1 | 1 | 1 | 46.9 | |||||
1 | 1 | 0 | 1.1 | 21.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
chronotype measurement | 0 | 1.1 | 83 | ||||
FEV/FEC ratio | 1 | 73.9 | |||||
0 | 1.1 | 59 | |||||
platelet count | 1 | 46.9 | |||||
0 | 1.1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | vezatin, adherens junctions transmembrane protein | VGNC:8590 | 452138 | |||||
Macaque | vezatin, adherens junctions transmembrane protein | 716675 | ||||||
Mouse | MGI:2143698 | 215008 | ||||||
Rat | RGD:1359117 | 299738 | ||||||
Dog | vezatin, adherens junctions transmembrane protein | VGNC:49719 | 111090044 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | vezatin, adherens junctions transmembrane protein | |||||
Macaque | vezatin, adherens junctions transmembrane protein | |||||
Mouse | ||||||
Rat | ||||||
Dog | vezatin, adherens junctions transmembrane protein | |||||
Publication Statistics
PubMed Score 20.18
PubMed score by year
PubTator Score 8.91
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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