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Tbio
VEZT
Vezatin

Protein Summary
Description
Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process. (Microbial infection) In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site. This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000436874
  • ENSP00000410083
  • ENSG00000028203
  • ENST00000546557
  • ENSP00000447080
  • ENST00000547484
  • ENSP00000447010
  • ENST00000547997
  • ENSP00000449346
  • ENST00000548455
  • ENSP00000447044
  • ENST00000549624
  • ENSP00000448555
  • ENST00000550803
  • ENSP00000449056
  • ENST00000552660
  • ENSP00000447786

Symbol
  • VEZATIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
virus perturbation
0.79
small molecule perturbation
0.75
kinase perturbation
0.71
microRNA
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.18   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.18   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999970869
p_ni:  0.000029131
Data Source:  BioPlex
C11orf87
Tdark
Novelty:  1.33249342
p_int:  0.999819466
p_ni:  0.00005104
p_wrong:  0.000129494
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.99966512
p_ni:  0.000334875
p_wrong:  4e-9
Data Source:  BioPlex
TMED6
Tdark
Novelty:  0.598611
p_int:  0.997033216
p_ni:  0.00286461
p_wrong:  0.000102174
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.995022721
p_ni:  0.004934604
p_wrong:  0.000042676
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.994386569
p_ni:  0.00555189
p_wrong:  0.000061541
Data Source:  BioPlex
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.99412136
p_ni:  0.005796337
p_wrong:  0.000082303
Data Source:  BioPlex
PLEKHO2
Tdark
Novelty:  0.48296621
p_int:  0.973192148
p_ni:  0.018949327
p_wrong:  0.007858524
Score:  0.28
Data Source:  BioPlex,STRINGDB
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.967568663
p_ni:  0.032407886
p_wrong:  0.00002345
Data Source:  BioPlex
CHRM4
Tclin
Family:  GPCR
Novelty:  0.00759817
p_int:  0.934630815
p_ni:  0.003564611
p_wrong:  0.061804575
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1.1
83
FEV/FEC ratio
1
1
1
73.9
2
2
0
1.1
59
platelet count
1
1
1
46.9
1
1
0
1.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1.1
83
FEV/FEC ratio
1
73.9
0
1.1
59
platelet count
1
46.9
0
1.1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vezatin, adherens junctions transmembrane protein
VGNC:8590
452138
Macaque
vezatin, adherens junctions transmembrane protein
716675
Mouse
MGI:2143698
215008
Rat
RGD:1359117
299738
Dog
vezatin, adherens junctions transmembrane protein
VGNC:49719
111090044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vezatin, adherens junctions transmembrane protein
Macaque
vezatin, adherens junctions transmembrane protein
Mouse
Rat
Dog
vezatin, adherens junctions transmembrane protein
Publication Statistics
PubMed Score 20.18
PubMed score by year
PubTator Score 8.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title