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Tbio
VDAC3
Voltage-dependent anion-selective channel protein 3

Protein Summary
Description
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000022615
  • ENSP00000022615
  • ENSG00000078668
  • ENST00000521158
  • ENSP00000428845

Symbol
  • VDAC-3
  • HD-VDAC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
co-expressed gene
0.94
molecular function
0.81
histone modification site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.02   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.02   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
APOE
Tbio
Novelty:  0.00005049
p_int:  0.999125127
p_ni:  0.000874846
p_wrong:  2.7e-8
Score:  0.225
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.995412425
p_ni:  0.004587565
p_wrong:  1e-8
Score:  0.2
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.977028169
p_ni:  0.022970652
p_wrong:  0.000001179
Score:  0.459
Data Source:  BioPlex,STRINGDB
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.969848434
p_ni:  0.030151566
Data Source:  BioPlex
ERICH5
Tdark
Novelty:  5.57504212
p_int:  0.967773473
p_ni:  0.01224866
p_wrong:  0.019977867
Score:  0.175
Data Source:  BioPlex,STRINGDB
FAM8A1
Tbio
Novelty:  0.08206001
p_int:  0.953831566
p_ni:  0.046168434
Data Source:  BioPlex
SPATA19
Tbio
Novelty:  0.06203122
p_int:  0.81407268
p_ni:  0.18592732
Score:  0.209
Data Source:  BioPlex,STRINGDB
RAP2A
Tbio
Family:  Enzyme
Novelty:  0.00541101
p_int:  0.751432182
p_ni:  0.248567266
p_wrong:  5.52e-7
Score:  0.222
Data Source:  BioPlex,STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.981
Data Source:  STRINGDB
PPIF
Tchem
Family:  Enzyme
Novelty:  0.00147732
Score:  0.972
Data Source:  STRINGDB
Pathways (26)
Deubiquitination (R-HSA-5688426)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Mitochondrial calcium ion transport
Reactome
Post-translational protein modification
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Mitochondrial calcium ion transport
Post-translational protein modification
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
81.9
self reported educational attainment
1
1
1
66.3
testosterone measurement
1
1
1
44.2
mean corpuscular volume
2
1
2
42.3
tissue plasminogen activator measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
81.9
self reported educational attainment
1
66.3
testosterone measurement
1
44.2
mean corpuscular volume
2
42.3
tissue plasminogen activator measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
voltage dependent anion channel 3
VGNC:6577
737891
Mouse
MGI:106922
22335
Rat
RGD:621577
83532
Dog
voltage dependent anion channel 3
VGNC:48248
606963
Horse
voltage dependent anion channel 3
VGNC:24897
100050036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
voltage dependent anion channel 3
Mouse
Rat
Dog
voltage dependent anion channel 3
Horse
voltage dependent anion channel 3
Publication Statistics
PubMed Score 95.02
PubMed score by year
PubTator Score 31.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title