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Tchem
VDAC2
Voltage-dependent anion-selective channel protein 2

Protein Summary
Description
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313132
  • ENSP00000361635
  • ENSG00000165637
  • ENST00000332211
  • ENSP00000361686
  • ENST00000543351
  • ENSP00000443092

Symbol
  • POR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
interacting protein
1
virus perturbation
0.96
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.22   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 196.22   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (185)
DENR
Tbio
Novelty:  0.00653432
p_int:  0.894247278
p_ni:  0.105752722
Score:  0.503
Data Source:  BioPlex,STRINGDB
VDAC1
Tbio
Novelty:  0.0011441
Score:  0.991
Data Source:  STRINGDB
TOMM20
Tbio
Novelty:  0.00275824
Score:  0.973
Data Source:  STRINGDB
TOMM70
Tbio
Novelty:  0.00943973
Score:  0.965
Data Source:  STRINGDB
SLC25A5
Tchem
Family:  Transporter
Novelty:  0.00749909
Score:  0.954
Data Source:  STRINGDB
RHOT1
Tbio
Family:  Enzyme
Novelty:  0.01411527
Score:  0.946
Data Source:  STRINGDB
ATP5F1C
Tbio
Family:  Enzyme
Novelty:  0.07666564
Score:  0.945
Data Source:  STRINGDB
B1AH88
Tchem
Novelty:  0.00082324
Score:  0.944
Data Source:  STRINGDB
P30536
Tchem
Novelty:  0.00082324
Score:  0.944
Data Source:  STRINGDB
PPIF
Tchem
Family:  Enzyme
Novelty:  0.00147732
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Mitochondrial calcium ion transport
Reactome
Post-translational protein modification
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Mitochondrial calcium ion transport
Post-translational protein modification
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
55.6
smoking initiation
1
1
1
7
smoking status measurement
1
1
1
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
55.6
smoking initiation
1
7
smoking status measurement
1
5.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
voltage-dependent anion-selective channel protein 2
471721
Macaque
voltage dependent anion channel 2
704257
Mouse
MGI:106915
22334
Rat
RGD:621576
83531
Dog
voltage dependent anion channel 2
VGNC:48247
479255
Species
Name
OMA
EggNOG
Inparanoid
Chimp
voltage-dependent anion-selective channel protein 2
Macaque
voltage dependent anion channel 2
Mouse
Rat
Dog
voltage dependent anion channel 2
Publication Statistics
PubMed Score 196.22
PubMed score by year
PubTator Score 69.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title