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Tbio
VCX3A
Variable charge X-linked protein 3

Protein Summary
Description
May mediate a process in spermatogenesis or may play a role in sex ratio distortion. This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 8 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381089
  • ENSP00000370479
  • ENSG00000169059

Symbol
  • VCX3
  • VCX8R
  • VCXA
  • VCX3
  • VCXA
  • VCX-A
  • VCX8R
  • VCX-8r
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.57
disease
0.44
cell line
0.42
tissue
0.37
biological term
0.35


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.56   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.56   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
PRKX
Tchem
Family:  Kinase
Novelty:  0.02599072
Score:  0.761
Data Source:  STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
Score:  0.75
Data Source:  STRINGDB
PUDP
Tbio
Family:  Enzyme
Novelty:  0.11180277
Score:  0.7
Data Source:  STRINGDB
PNPLA4
Tbio
Family:  Enzyme
Novelty:  0.07471752
Score:  0.669
Data Source:  STRINGDB
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
Score:  0.629
Data Source:  STRINGDB
EDC3
Tbio
Novelty:  0.02077346
Score:  0.592
Data Source:  STRINGDB
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
Score:  0.587
Data Source:  STRINGDB
EDC4
Tbio
Novelty:  0.00365253
Score:  0.577
Data Source:  STRINGDB
SHOX
Tbio
Family:  TF
Novelty:  0.00259568
Score:  0.56
Data Source:  STRINGDB
ANOS1
Tbio
Novelty:  0.00254765
Score:  0.542
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
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GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 15.56
PubMed score by year
PubTator Score 9.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title