Tbio VCPKMT Protein-lysine methyltransferase METTL21D

Protein Summary

Description

Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.

Uniprot Accession IDs

• Q9H867
• B7ZLA3
• B7ZLA4
• Q2M2X3
• Q86T12

Gene Name

• VCPKMT

Ensembl ID

• ENST00000395859
• ENSP00000379200
• ENSG00000100483
• ENST00000395860
• ENSP00000379201
• ENST00000491402
• ENSP00000437113

Symbol

• C14orf138
• METTL21D
• VCP-KMT
• METTL21D
• C14orf138

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
transcription factor	0.75
transcription factor binding site profile	0.73
tissue sample	0.68
cell type or tissue	0.64

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Writer / Protein Methyltransferase / Protein-lysine Methyltransferase Mettl21d

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 20   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0