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Tbio
VCPKMT
Protein-lysine methyltransferase METTL21D

Protein Summary
Description
Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395859
  • ENSP00000379200
  • ENSG00000100483
  • ENST00000395860
  • ENSP00000379201
  • ENST00000491402
  • ENSP00000437113

Symbol
  • C14orf138
  • METTL21D
  • VCP-KMT
  • METTL21D
  • C14orf138
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor
0.75
transcription factor binding site profile
0.73
tissue sample
0.68
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0