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Tchem
VCP
Transitional endoplasmic reticulum ATPase

Protein Summary
Description
Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358901
  • ENSP00000351777
  • ENSG00000165280

Symbol
  • p97
  • TERA
  • CDC48
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
1
protein domain
1
kinase perturbation
0.99
biological process
0.98


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1283.83   (req: < 5)
Gene RIFs: 236   (req: <= 3)
Antibodies: 590   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1283.83   (req: >= 5)
Gene RIFs: 236   (req: > 3)
Antibodies: 590   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 238
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0