Tbio VCL Vinculin

Protein Summary

Description

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P18206
• Q16450
• Q5SWX2
• Q7Z3B8
• Q8IXU7

Gene Name

• VCL

Ensembl ID

• ENST00000211998
• ENSP00000211998
• ENSG00000035403
• ENST00000372755
• ENSP00000361841

Symbol

• MV
• MVCL
• CMD1W
• CMH15
• HEL114

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
interacting protein	0.97
virus perturbation	0.96
transcription factor binding site profile	0.92
hub protein	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2469.09   (req: < 5)

Gene RIFs: 85   (req: <= 3)

Antibodies: 810   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2469.09   (req: >= 5)

Gene RIFs: 85   (req: > 3)

Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0