Protein Summary
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
- ENST00000211998
- ENSP00000211998
- ENSG00000035403
- ENST00000372755
- ENSP00000361841
- MV
- MVCL
- CMD1W
- CMH15
- HEL114
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
interacting protein | 0.97 | ||
virus perturbation | 0.96 | ||
transcription factor binding site profile | 0.92 | ||
hub protein | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2197.69 (req: < 5)
Gene RIFs: 85 (req: <= 3)
Antibodies: 810 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2197.69 (req: >= 5)
Gene RIFs: 85 (req: > 3)
Antibodies: 810 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (448)
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
1 – 2 of 2
Pathways (77)
Reactome (26)
KEGG (7)
PathwayCommons (9)
WikiPathways (35)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | FLT3 Signaling | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Disease | ||||
Diseases of signal transduction | ||||
FLT3 Signaling | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (47)
Functions (7)
Components (26)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urokinase plasminogen activator surface receptor measurement | 1 | 1 | 1 | 82.3 | |||||
1 | 1 | 0 | 1.1 | 56.8 | |||||
1 | 1 | 0 | 1.1 | 37.6 | |||||
cardiac troponin I measurement | 1 | 1 | 1 | 31.4 | |||||
left ventricular diastolic function measurement | 1 | 1 | 1 | 24.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urokinase plasminogen activator surface receptor measurement | 1 | 82.3 | |||||
0 | 1.1 | 56.8 | |||||
0 | 1.1 | 37.6 | |||||
cardiac troponin I measurement | 1 | 31.4 | |||||
left ventricular diastolic function measurement | 1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | vinculin | VGNC:5875 | 450531 | |||||
Mouse | MGI:98927 | 22330 | ||||||
Rat | RGD:1311217 | 305679 | ||||||
Dog | vinculin | VGNC:48242 | 479252 | |||||
Horse | vinculin | VGNC:24892 | 100064165 | |||||
Publication Statistics
PubMed Score 2197.69
PubMed score by year
PubTator Score 1276.07
PubTator score by year
Related Publications
Text Mined References (154)
GeneRif Annotations (85)
Items per page:
0 of 0
PMID | Year | Title |
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