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Tchem
VCAM1
Vascular cell adhesion protein 1

Protein Summary
Description
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294728
  • ENSP00000294728
  • ENSG00000162692
  • ENST00000347652
  • ENSP00000304611
  • ENST00000370119
  • ENSP00000359137

Symbol
  • CD106
  • INCAM-100
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
protein domain
0.99
biological process
0.93
interacting protein
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4371.44   (req: < 5)
Gene RIFs: 414   (req: <= 3)
Antibodies: 1863   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4371.44   (req: >= 5)
Gene RIFs: 414   (req: > 3)
Antibodies: 1863   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (524)
SEMA4D
Tbio
Novelty:  0.0043592
p_int:  0.999612167
p_ni:  0.000387833
Score:  0.261
Data Source:  BioPlex,STRINGDB
FANK1
Tbio
Novelty:  0.12389783
p_int:  0.994840579
p_ni:  0.001155938
p_wrong:  0.004003483
Score:  0.19
Data Source:  BioPlex,STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
p_int:  0.991876045
p_ni:  0.00812326
p_wrong:  6.95e-7
Score:  0.19
Data Source:  BioPlex,STRINGDB
PODXL2
Tbio
Novelty:  0.09100487
p_int:  0.991496094
p_ni:  0.008047043
p_wrong:  0.000456862
Score:  0.232
Data Source:  BioPlex,STRINGDB
APOA1
Tbio
Novelty:  0.0001216
p_int:  0.918577288
p_ni:  0.081422164
p_wrong:  5.48e-7
Score:  0.733
Data Source:  BioPlex,STRINGDB
INTS8
Tdark
Novelty:  0.03933008
p_int:  0.868540903
p_ni:  0.101526826
p_wrong:  0.029932271
Score:  0.309
Data Source:  BioPlex,STRINGDB
WDFY3
Tbio
Novelty:  0.01670166
p_int:  0.762086734
p_ni:  0.237912415
p_wrong:  8.51e-7
Score:  0.407
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.754681962
p_ni:  0.245318038
Data Source:  BioPlex
TNF
Tclin
Novelty:  0.00001457
Score:  0.994
Data Source:  STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.987
Data Source:  STRINGDB
Pathways (33)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Extracellular matrix organization
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cytokine Signaling in Immune system
Extracellular matrix organization
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
3
3
86.7
monocyte count
2
2
2
86.5
neutrophil percentage of leukocytes
2
3
3
79.9
lymphocyte percentage of leukocytes
2
3
3
74.5
leukocyte count
1
2
2
68.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
86.7
monocyte count
2
86.5
neutrophil percentage of leukocytes
3
79.9
lymphocyte percentage of leukocytes
3
74.5
leukocyte count
2
68.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vascular cell adhesion molecule 1
VGNC:1639
457059
Macaque
vascular cell adhesion molecule 1
712036
Mouse
MGI:98926
22329
Rat
RGD:3952
25361
Dog
vascular cell adhesion molecule 1
VGNC:48240
403982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vascular cell adhesion molecule 1
Macaque
vascular cell adhesion molecule 1
Mouse
Rat
Dog
vascular cell adhesion molecule 1
Publication Statistics
PubMed Score 4371.44
PubMed score by year
PubTator Score 2359.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title