VCAM1
Vascular cell adhesion protein 1
Protein Summary
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
- ENST00000294728
- ENSP00000294728
- ENSG00000162692
- ENST00000347652
- ENSP00000304611
- ENST00000370119
- ENSP00000359137
- CD106
- INCAM-100
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
protein domain | 0.99 | ||
biological process | 0.93 | ||
interacting protein | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4745.2 (req: < 5)
Gene RIFs: 483 (req: <= 3)
Antibodies: 1863 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4745.2 (req: >= 5)
Gene RIFs: 483 (req: > 3)
Antibodies: 1863 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 28
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0