Tchem VAV1 Proto-oncogene vav

Protein Summary

Description

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• P15498
• B4DVK9
• M0QXX6
• Q15860

Gene Name

• VAV1

Ensembl ID

• ENST00000596764
• ENSP00000469450
• ENSG00000141968
• ENST00000602142
• ENSP00000472929

Symbol

• VAV
• VAV

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	1
kinase perturbation	0.96
disease perturbation	0.93
biological process	0.89

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.97   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 701   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 578.97   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

phorbol 12,13-dibutyrate

VAV1Tchem

pKd : 8.98

Protein-Protein Interactions (368)

Explore Interacting Targets

1 – 10 of 368

• See Interactions on String-DB

KLK7

Tchem

Family:  Enzyme

Novelty:  0.00757766

p_int:  0.999848797

p_ni:  0.000151012

p_wrong:  1.92e-7

Data Source:  BioPlex

PLBD1

Tdark

Family:  Enzyme

Novelty:  0.27639575

p_int:  0.999614801

p_ni:  0.000385197

p_wrong:  2e-9

Score:  0.206

Data Source:  BioPlex,STRINGDB

NUB1

Tbio

Novelty:  0.00736082

p_int:  0.999136087

p_ni:  0.000001684

p_wrong:  0.000862228

Score:  0.277

Data Source:  BioPlex,STRINGDB

SPECC1L

Tbio

Novelty:  0.06116909

p_int:  0.995856446

p_ni:  0.004143554

Data Source:  BioPlex

SERPINA12

Tbio

Novelty:  0.00549132

p_int:  0.994227541

p_ni:  0.005772438

p_wrong:  2.1e-8

Data Source:  BioPlex

APLP2

Tbio

Novelty:  0.0082936

p_int:  0.98734576

p_ni:  0.01265424

Score:  0.534

Data Source:  BioPlex,STRINGDB

ACTBL2

Tbio

Novelty:  0.18080702

p_int:  0.983147033

p_ni:  0.016852967

Data Source:  BioPlex

SDR9C7

Tbio

Family:  Enzyme

Novelty:  0.01618496

p_int:  0.980589837

p_ni:  0.019206545

p_wrong:  0.000203619

Data Source:  BioPlex

SERPINB2

Tbio

Novelty:  0.00204345

p_int:  0.96497537

p_ni:  0.030302546

p_wrong:  0.004722084

Score:  0.18

Data Source:  BioPlex,STRINGDB

APBB2

Tbio

Novelty:  0.06546724

p_int:  0.958721181

p_ni:  0.04102177

p_wrong:  0.00025705

Data Source:  BioPlex

Nearest Tclin Targets (6)

Explore Nearest Tclin Targets

Upstream (4)

Downstream (2)

1 – 4 of 4

PIK3CA

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  13

1: Focal adhesion

2: T cell receptor signaling pathway

3: B cell receptor signaling pathway

4: Fc epsilon RI signaling pathway

more:  9 more common pathways

PIK3CD

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  13

1: Focal adhesion

2: T cell receptor signaling pathway

3: B cell receptor signaling pathway

4: Fc epsilon RI signaling pathway

more:  9 more common pathways

ITK

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  3

1: T cell receptor signaling pathway

2: Chemokine signaling pathway

3: Leukocyte transendothelial migration

CD19

Tclin

Family:  Other

KEGG Distance:  1

Common Pathways:  1

1: B cell receptor signaling pathway

Pathways (99)

Reactome (45)

KEGG (13)

PathwayCommons (27)

WikiPathways (14)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695
Reactome	CD28 co-stimulation	33 targets	R-HSA-389356
Reactome	CD28 dependent Vav1 pathway	12 targets	R-HSA-389359
Reactome	Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	92 targets	R-HSA-983695
CD28 co-stimulation	33 targets	R-HSA-389356
CD28 dependent Vav1 pathway	12 targets	R-HSA-389359
Cell death signalling via NRAGE, NRIF and NADE	76 targets	R-HSA-204998

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (32)

Functions (7)

Components (3)

Processes (22)

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1 – 7 of 7

GO Term	Evidence	Assigned by
guanyl-nucleotide exchange factor activity	Inferred from Experiment (EXP)	Reactome
phosphotyrosine residue binding	Inferred from Physical Interaction (IPI)	CAFA
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Traceable Author Statement (TAS)	Reactome
Rho guanyl-nucleotide exchange factor activity	Traceable Author Statement (TAS)	Reactome
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
Rac guanyl-nucleotide exchange factor activity	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (16)

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1 – 5 of 16

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age-related macular degeneration	EFO_0001365	7	3	0	1.4	96.9
mean platelet volume	EFO_0004584	3	3	5		96
wet macular degeneration	EFO_0004683	2	2	0	1.6	94.1
atrophic macular degeneration	EFO_1001492	2	2	0	1.8	94.1
lymphocyte count	EFO_0004587	2	2	3		77.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age-related macular degeneration	EFO_0001365	0	1.4	96.9
mean platelet volume	EFO_0004584	5		96
wet macular degeneration	EFO_0004683	0	1.6	94.1
atrophic macular degeneration	EFO_1001492	0	1.8	94.1
lymphocyte count	EFO_0004587	3		77.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Guanine-nucleotide releasing factor
Metal-binding
Phosphoprotein
Polymorphism
Proto-oncogene
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
age-related macular degeneration
atrophic macular degeneration
body mass index
complement C3 measurement
complement C4 measurement
disease progression measurement
leukocyte count
lymphocyte count
mean platelet volume
monocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	vav guanine nucleotide exchange factor 1	VGNC:2419	455647
Macaque	vav guanine nucleotide exchange factor 1		100424246
Mouse	vav 1 oncogene	MGI:98923	22324
Rat	vav guanine nucleotide exchange factor 1	RGD:3951	25156
Dog	vav guanine nucleotide exchange factor 1	VGNC:48236	485016

Species	Name	OMA	EggNOG	Inparanoid
Chimp	vav guanine nucleotide exchange factor 1
Macaque	vav guanine nucleotide exchange factor 1
Mouse	vav 1 oncogene
Rat	vav guanine nucleotide exchange factor 1
Dog	vav guanine nucleotide exchange factor 1

Publication Statistics

PubMed Score 578.97

PubMed score by year

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PubTator Score 353.02

PubTator score by year

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Related Publications

Text Mined References (188)

GeneRif Annotations (95)

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10

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PMID	Year	Title