Protein Summary
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]
- ENST00000596764
- ENSP00000469450
- ENSG00000141968
- ENST00000602142
- ENSP00000472929
- VAV
- VAV
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
protein domain | 1 | ||
kinase perturbation | 0.96 | ||
disease perturbation | 0.93 | ||
biological process | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 578.97 (req: < 5)
Gene RIFs: 95 (req: <= 3)
Antibodies: 701 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 578.97 (req: >= 5)
Gene RIFs: 95 (req: > 3)
Antibodies: 701 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (368)
KLK7
Family: Enzyme
Novelty: 0.00757766
p_int: 0.999848797
p_ni: 0.000151012
p_wrong: 1.92e-7
Data Source: BioPlex
PLBD1
Family: Enzyme
Novelty: 0.27639575
p_int: 0.999614801
p_ni: 0.000385197
p_wrong: 2e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
NUB1
Novelty: 0.00736082
p_int: 0.999136087
p_ni: 0.000001684
p_wrong: 0.000862228
Score: 0.277
Data Source: BioPlex,STRINGDB
SERPINA12
Novelty: 0.00549132
p_int: 0.994227541
p_ni: 0.005772438
p_wrong: 2.1e-8
Data Source: BioPlex
APLP2
Novelty: 0.0082936
p_int: 0.98734576
p_ni: 0.01265424
Score: 0.534
Data Source: BioPlex,STRINGDB
SDR9C7
Family: Enzyme
Novelty: 0.01618496
p_int: 0.980589837
p_ni: 0.019206545
p_wrong: 0.000203619
Data Source: BioPlex
SERPINB2
Novelty: 0.00204345
p_int: 0.96497537
p_ni: 0.030302546
p_wrong: 0.004722084
Score: 0.18
Data Source: BioPlex,STRINGDB
APBB2
Novelty: 0.06546724
p_int: 0.958721181
p_ni: 0.04102177
p_wrong: 0.00025705
Data Source: BioPlex
Nearest Tclin Targets (6)
Upstream (4)
Downstream (2)
1 – 4 of 4
Pathways (99)
Reactome (45)
KEGG (13)
PathwayCommons (27)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
Reactome | CD28 co-stimulation | ||||
Reactome | CD28 dependent Vav1 pathway | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
CD28 co-stimulation | ||||
CD28 dependent Vav1 pathway | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (7)
Components (3)
Processes (22)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
7 | 3 | 0 | 1.4 | 96.9 | |||||
mean platelet volume | 3 | 3 | 5 | 96 | |||||
2 | 2 | 0 | 1.6 | 94.1 | |||||
atrophic macular degeneration | 2 | 2 | 0 | 1.8 | 94.1 | ||||
lymphocyte count | 2 | 2 | 3 | 77.6 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.4 | 96.9 | |||||
mean platelet volume | 5 | 96 | |||||
0 | 1.6 | 94.1 | |||||
atrophic macular degeneration | 0 | 1.8 | 94.1 | ||||
lymphocyte count | 3 | 77.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | vav guanine nucleotide exchange factor 1 | VGNC:2419 | 455647 | |||||
Macaque | vav guanine nucleotide exchange factor 1 | 100424246 | ||||||
Mouse | MGI:98923 | 22324 | ||||||
Rat | RGD:3951 | 25156 | ||||||
Dog | vav guanine nucleotide exchange factor 1 | VGNC:48236 | 485016 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | vav guanine nucleotide exchange factor 1 | |||||
Macaque | vav guanine nucleotide exchange factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | vav guanine nucleotide exchange factor 1 | |||||
Publication Statistics
PubMed Score 578.97
PubMed score by year
PubTator Score 353.02
PubTator score by year
Related Publications
Text Mined References (188)
GeneRif Annotations (95)
Items per page:
0 of 0
PMID | Year | Title |
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