Tbio VASH1 Tubulinyl-Tyr carboxypeptidase 1

Protein Summary

Description

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).

Uniprot Accession IDs

• Q7L8A9
• Q96H02
• Q9UBF4
• Q9Y629

Gene Name

• VASH1

Ensembl ID

• ENST00000167106
• ENSP00000167106
• ENSG00000071246
• ENST00000554237
• ENSP00000451613

Symbol

• KIAA1036
• VASH
• TTCP 1
• KIAA1036

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.79
transcription factor perturbation	0.74
disease perturbation	0.62
PubMedID	0.62
microRNA	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.83   (req: < 5)

Gene RIFs: 70   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.83   (req: >= 5)

Gene RIFs: 70   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0