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Tchem
VARS
Valine--tRNA ligase

Protein Summary
Description
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211402
  • ENSP00000211402
  • ENSG00000096171
  • ENST00000375663
  • ENSP00000364815
  • ENSG00000204394
  • ENST00000422694
  • ENSP00000401121
  • ENSG00000224264
  • ENST00000435657
  • ENSP00000415316
  • ENSG00000231116
  • ENST00000457796
  • ENSP00000403359
  • ENSG00000226589

Symbol
  • G7A
  • VARS2
  • G7A
  • VARS1
  • VARS2
  • NDMSCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.95
interacting protein
0.94
transcription factor perturbation
0.84
protein complex
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.58   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.58   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0