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Tchem
VARS
Valine--tRNA ligase

Protein Summary
Description
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211402
  • ENSP00000211402
  • ENSG00000096171
  • ENST00000375663
  • ENSP00000364815
  • ENSG00000204394
  • ENST00000422694
  • ENSP00000401121
  • ENSG00000224264
  • ENST00000435657
  • ENSP00000415316
  • ENSG00000231116
  • ENST00000457796
  • ENSP00000403359
  • ENSG00000226589

Symbol
  • G7A
  • VARS2
  • G7A
  • VARS1
  • VARS2
  • NDMSCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.95
interacting protein
0.94
transcription factor perturbation
0.84
protein complex
0.81


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 140.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (296)
EEF1A1
Tchem
Novelty:  0.00059953
p_int:  0.99997119
p_ni:  0.000028809
p_wrong:  1e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
EEF1D
Tbio
Novelty:  0.02480745
p_int:  0.999911839
p_ni:  0.000088161
Score:  0.939
Data Source:  BioPlex,STRINGDB
EEF1G
Tbio
Novelty:  0.01473013
p_int:  0.999629132
p_ni:  0.000370867
Score:  0.9
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.999584797
p_ni:  0.000415153
p_wrong:  5e-8
Score:  0.89
Data Source:  BioPlex,STRINGDB
MLLT6
Tdark
Family:  Epigenetic
Novelty:  0.03728427
p_int:  0.997281239
p_ni:  0.002718761
Score:  0.564
Data Source:  BioPlex,STRINGDB
ABTB1
Tbio
Novelty:  0.08918942
p_int:  0.990772045
p_ni:  0.009227954
Score:  0.867
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.984657165
p_ni:  0.015342835
Score:  0.224
Data Source:  BioPlex,STRINGDB
CEBPG
Tbio
Family:  TF
Novelty:  0.07956633
p_int:  0.98269985
p_ni:  0.01730015
Data Source:  BioPlex
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.970046765
p_ni:  0.029953234
Score:  0.176
Data Source:  BioPlex,STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
p_int:  0.894856956
p_ni:  0.105143044
Score:  0.303
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (320)
Items per page:
1 – 5 of 320
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
12
15
97.8
BMI-adjusted waist-hip ratio
5
12
15
97.8
BMI-adjusted waist-hip ratio
5
12
15
97.8
BMI-adjusted waist-hip ratio
5
12
15
97.8
BMI-adjusted waist-hip ratio
5
12
15
97.8
Items per page:
1 – 5 of 320
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
15
97.8
BMI-adjusted waist-hip ratio
15
97.8
BMI-adjusted waist-hip ratio
15
97.8
BMI-adjusted waist-hip ratio
15
97.8
BMI-adjusted waist-hip ratio
15
97.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
valyl-tRNA synthetase
715537
Mouse
MGI:90675
22321
Rat
RGD:3950
25009
Dog
valyl-tRNA synthetase
VGNC:48231
481716
Horse
valyl-tRNA synthetase
VGNC:24882
100058924
Species
Name
OMA
EggNOG
Inparanoid
Macaque
valyl-tRNA synthetase
Mouse
Rat
Dog
valyl-tRNA synthetase
Horse
valyl-tRNA synthetase
Publication Statistics
PubMed Score 140.72
PubMed score by year
PubTator Score 47.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title