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Tbio
VANGL1
Vang-like protein 1

Protein Summary
Description
This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310260
  • ENSP00000310800
  • ENSG00000173218
  • ENST00000355485
  • ENSP00000347672
  • ENST00000369509
  • ENSP00000358522
  • ENST00000369510
  • ENSP00000358523

Symbol
  • STB2
  • LPP2
  • STB2
  • STBM2
  • KITENIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
transcription factor binding site profile
0.81
PubMedID
0.73
virus perturbation
0.72
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.88   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.88   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.99999072
p_ni:  0.00000928
Data Source:  BioPlex
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999986677
p_ni:  0.000013323
Data Source:  BioPlex
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999856775
p_ni:  0.000143225
Data Source:  BioPlex
EPB41L1
Tbio
Novelty:  0.02937451
p_int:  0.999695322
p_ni:  0.000304678
Data Source:  BioPlex
DVL2
Tbio
Novelty:  0.00833084
p_int:  0.999615176
p_ni:  0.000384824
Score:  0.977
Data Source:  BioPlex,STRINGDB
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999087781
p_ni:  0.000912219
Score:  0.209
Data Source:  BioPlex,STRINGDB
DVL3
Tbio
Novelty:  0.01606014
p_int:  0.998701056
p_ni:  0.001298944
Score:  0.977
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.99861114
p_ni:  0.00138886
Data Source:  BioPlex
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.997150325
p_ni:  0.002849675
Data Source:  BioPlex
PNN
Tbio
Novelty:  0.01395394
p_int:  0.996958394
p_ni:  0.003041606
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
2
2
89.2
electrocardiography
1
1
20
78
2
2
0
1.1
77.6
left atrial function
2
1
2
59.5
heart function measurement
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
2
89.2
electrocardiography
20
78
0
1.1
77.6
left atrial function
2
59.5
heart function measurement
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2159344
229658
Rat
RGD:1597324
690366
Dog
VANGL planar cell polarity protein 1
VGNC:48228
483133
Horse
VANGL planar cell polarity protein 1
VGNC:24880
100059585
Cow
VANGL planar cell polarity protein 1
VGNC:36761
513056
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
VANGL planar cell polarity protein 1
Horse
VANGL planar cell polarity protein 1
Cow
VANGL planar cell polarity protein 1
Publication Statistics
PubMed Score 116.88
PubMed score by year
PubTator Score 39.97
PubTator score by year
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Related Publications
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PMID
Year
Title