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Tbio
VAMP4
Vesicle-associated membrane protein 4

Protein Summary
Description
Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236192
  • ENSP00000236192
  • ENSG00000117533
  • ENST00000367740
  • ENSP00000356714
  • ENST00000474047
  • ENSP00000435933

Symbol
  • VAMP-4
  • VAMP24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
histone modification site profile
0.9
transcription factor binding site profile
0.86
transcription factor perturbation
0.84
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (282)
NAPG
Tbio
Novelty:  0.02295985
p_int:  0.999999999
p_ni:  1e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.999999916
p_ni:  8.4e-8
Score:  0.956
Data Source:  BioPlex,STRINGDB
NTMT1
Tchem
Family:  Enzyme
Novelty:  0.06322967
p_int:  0.99999951
p_ni:  4.89e-7
p_wrong:  1e-9
Score:  0.38
Data Source:  BioPlex,STRINGDB
WASHC1
Tbio
Novelty:  0.09242196
p_int:  0.999998668
p_ni:  0.000001047
p_wrong:  2.85e-7
Data Source:  BioPlex
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999997527
p_ni:  0.000002473
Score:  0.948
Data Source:  BioPlex,STRINGDB
NAPB
Tdark
Novelty:  0.31464404
p_int:  0.999982921
p_ni:  9.18e-7
p_wrong:  0.000016161
Score:  0.955
Data Source:  BioPlex,STRINGDB
NBAS
Tbio
Novelty:  0.01187862
p_int:  0.999953774
p_ni:  0.000046226
Score:  0.676
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999945909
p_ni:  0.000054091
Score:  0.975
Data Source:  BioPlex,STRINGDB
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.999932276
p_ni:  0.000067724
Data Source:  BioPlex
COX6B1
Tbio
Family:  Enzyme
Novelty:  0.02531055
p_int:  0.999913139
p_ni:  0.000041087
p_wrong:  0.000045775
Score:  0.154
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
78.1
intelligence
1
1
0
5.9
31.4
self reported educational attainment
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
78.1
intelligence
0
5.9
31.4
self reported educational attainment
1
2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 4
VGNC:7023
457513
Macaque
vesicle associated membrane protein 4
704733
Mouse
MGI:1858730
53330
Rat
RGD:1309753
364033
Dog
vesicle associated membrane protein 4
VGNC:48224
106559029
Species
Name
OMA
EggNOG
Inparanoid
Chimp
vesicle associated membrane protein 4
Macaque
vesicle associated membrane protein 4
Mouse
Rat
Dog
vesicle associated membrane protein 4
Publication Statistics
PubMed Score 32.32
PubMed score by year
PubTator Score 17.60
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title