Tbio VAMP2 Vesicle-associated membrane protein 2

Protein Summary

Description

Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P63027
• P19065
• Q9BUC2
• VAMP-2

Gene Name

• VAMP2

Ensembl ID

• ENST00000316509
• ENSP00000314214
• ENSG00000220205

Symbol

• SYB2
• SYB2
• VAMP-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
disease perturbation	0.95
protein complex	0.94
cellular component	0.89
histone modification site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.25   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 265   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.25   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0