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Tbio
UXS1
UDP-glucuronic acid decarboxylase 1

Protein Summary
Description
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283148
  • ENSP00000283148
  • ENSG00000115652
  • ENST00000409032
  • ENSP00000387096
  • ENST00000409501
  • ENSP00000387019

Symbol
  • UGD
  • SDR6E1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.81
transcription factor perturbation
0.8
molecular function
0.76
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.1   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.1   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
SPSB3
Tdark
Novelty:  0.07215887
p_int:  0.999981755
p_ni:  0.000018245
Data Source:  BioPlex
TSKU
Tbio
Novelty:  0.01876348
p_int:  0.999958543
p_ni:  8e-9
p_wrong:  0.000041449
Score:  0.222
Data Source:  BioPlex,STRINGDB
PEX19
Tbio
Novelty:  0.00605342
p_int:  0.999913568
p_ni:  0.000086432
Data Source:  BioPlex
NOP9
Tdark
Novelty:  2.89535198
p_int:  0.999836478
p_ni:  0.000163521
p_wrong:  1e-9
Data Source:  BioPlex
ANK3
Tbio
Novelty:  0.00429246
p_int:  0.999783239
p_ni:  0.000216761
Score:  0.156
Data Source:  BioPlex,STRINGDB
XPO4
Tbio
Novelty:  0.01507446
p_int:  0.999774541
p_ni:  0.000225459
Data Source:  BioPlex
VPS8
Tbio
Novelty:  0.05178496
p_int:  0.999511059
p_ni:  0.00048892
p_wrong:  2.1e-8
Data Source:  BioPlex
FAM98A
Tdark
Novelty:  0.30067413
p_int:  0.999431363
p_ni:  0.000568637
Data Source:  BioPlex
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.998710724
p_ni:  0.001289235
p_wrong:  4.2e-8
Data Source:  BioPlex
GIP
Tbio
Novelty:  0.0007219
p_int:  0.996841671
p_ni:  0.003158329
Data Source:  BioPlex
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
3
3
62
1
1
0
1.9
24.5
1
1
0
1.9
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
62
0
1.9
24.5
0
1.9
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-glucuronate decarboxylase 1
VGNC:10807
470464
Macaque
UDP-glucuronate decarboxylase 1
718456
Mouse
MGI:1915133
67883
Rat
RGD:628680
246232
Dog
UDP-glucuronate decarboxylase 1
VGNC:48220
481318
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-glucuronate decarboxylase 1
Macaque
UDP-glucuronate decarboxylase 1
Mouse
Rat
Dog
UDP-glucuronate decarboxylase 1
Publication Statistics
PubMed Score 22.10
PubMed score by year
PubTator Score 3.35
PubTator score by year
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Related Publications
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PMID
Year
Title