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Tchem
UTRN
Utrophin

Protein Summary
Description
May play a role in anchoring the cytoskeleton to the plasma membrane. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367545
  • ENSP00000356515
  • ENSG00000152818

Symbol
  • DMDL
  • DRP1
  • DRP
  • DMDL
  • DRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.97
microRNA
0.77
interacting protein
0.76
trait
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.4   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 563.4   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (35)
Protein-Protein Interactions (168)
SNTG2
Tbio
Novelty:  0.04056715
p_int:  0.999999646
p_ni:  3.54e-7
Score:  0.933
Data Source:  BioPlex,STRINGDB
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999997
p_ni:  0.000002999
p_wrong:  1e-9
Score:  0.72
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999980912
p_ni:  0.000019088
Score:  0.283
Data Source:  BioPlex,STRINGDB
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999897151
p_ni:  0.000102849
Score:  0.933
Data Source:  BioPlex,STRINGDB
TAGAP
Tbio
Family:  Enzyme
Novelty:  0.04450409
p_int:  0.999870122
p_ni:  0.000129877
p_wrong:  1e-9
Data Source:  BioPlex
CPNE5
Tbio
Novelty:  0.09416684
p_int:  0.999863662
p_ni:  0.000136338
Score:  0.156
Data Source:  BioPlex,STRINGDB
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999180186
p_ni:  0.00012629
p_wrong:  0.000693525
Score:  0.775
Data Source:  BioPlex,STRINGDB
L3HYPDH
Tdark
Family:  Enzyme
Novelty:  0.35456591
p_int:  0.998757677
p_ni:  0.001242323
Score:  0.228
Data Source:  BioPlex,STRINGDB
FAM167A
Tbio
Novelty:  0.05232679
p_int:  0.997468867
p_ni:  0.002531133
Score:  0.169
Data Source:  BioPlex,STRINGDB
GNA13
Tbio
Novelty:  0.04149138
p_int:  0.993777738
p_ni:  0.006221862
p_wrong:  4e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (45)
Find Similar Targets
Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Primary Focal Segmental Glomerulosclerosis FSGS
WikiPathways
Primary Focal Segmental Glomerulosclerosis FSGS
WikiPathways
Hepatitis C and Hepatocellular Carcinoma
WikiPathways
Differentiation Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
Name
Explore in Pharos
Explore in Source
Primary Focal Segmental Glomerulosclerosis FSGS
Primary Focal Segmental Glomerulosclerosis FSGS
Hepatitis C and Hepatocellular Carcinoma
Differentiation Pathway
Nuclear Receptors Meta-Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
49.5
testosterone measurement
1
1
1
37.6
multisite chronic pain
1
1
1
26.6
mathematical ability
1
1
1
21.5
smoking status measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
49.5
testosterone measurement
1
37.6
multisite chronic pain
1
26.6
mathematical ability
1
21.5
smoking status measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
utrophin
VGNC:3784
463046
Macaque
utrophin
699498
Mouse
MGI:104631
22288
Rat
RGD:3947
25600
Dog
utrophin
VGNC:48215
442965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
utrophin
Macaque
utrophin
Mouse
Rat
Dog
utrophin
Publication Statistics
PubMed Score 563.40
PubMed score by year
PubTator Score 198.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title