Protein Summary
May play a role in anchoring the cytoskeleton to the plasma membrane. This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
- ENST00000367545
- ENSP00000356515
- ENSG00000152818
- DMDL
- DRP1
- DRP
- DMDL
- DRP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
transcription factor perturbation | 0.97 | ||
microRNA | 0.77 | ||
interacting protein | 0.76 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 563.4 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 563.4 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 35
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (35)
Protein-Protein Interactions (168)
SNTG2
Novelty: 0.04056715
p_int: 0.999999646
p_ni: 3.54e-7
Score: 0.933
Data Source: BioPlex,STRINGDB
DTNB
Novelty: 0.0586565
p_int: 0.999997
p_ni: 0.000002999
p_wrong: 1e-9
Score: 0.72
Data Source: BioPlex,STRINGDB
NDEL1
Novelty: 0.01241819
p_int: 0.999980912
p_ni: 0.000019088
Score: 0.283
Data Source: BioPlex,STRINGDB
DMD
Novelty: 0.00025661
p_int: 0.999897151
p_ni: 0.000102849
Score: 0.933
Data Source: BioPlex,STRINGDB
TAGAP
Family: Enzyme
Novelty: 0.04450409
p_int: 0.999870122
p_ni: 0.000129877
p_wrong: 1e-9
Data Source: BioPlex
CPNE5
Novelty: 0.09416684
p_int: 0.999863662
p_ni: 0.000136338
Score: 0.156
Data Source: BioPlex,STRINGDB
SNTG1
Novelty: 0.05608114
p_int: 0.999180186
p_ni: 0.00012629
p_wrong: 0.000693525
Score: 0.775
Data Source: BioPlex,STRINGDB
L3HYPDH
Family: Enzyme
Novelty: 0.35456591
p_int: 0.998757677
p_ni: 0.001242323
Score: 0.228
Data Source: BioPlex,STRINGDB
FAM167A
Novelty: 0.05232679
p_int: 0.997468867
p_ni: 0.002531133
Score: 0.169
Data Source: BioPlex,STRINGDB
GNA13
Novelty: 0.04149138
p_int: 0.993777738
p_ni: 0.006221862
p_wrong: 4e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (45)
WikiPathways (45)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
WikiPathways | Hepatitis C and Hepatocellular Carcinoma | ||||
WikiPathways | Differentiation Pathway | ||||
WikiPathways | Nuclear Receptors Meta-Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Primary Focal Segmental Glomerulosclerosis FSGS | ||||
Hepatitis C and Hepatocellular Carcinoma | ||||
Differentiation Pathway | ||||
Nuclear Receptors Meta-Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (6)
Components (16)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 1 | 1 | 49.5 | |||||
testosterone measurement | 1 | 1 | 1 | 37.6 | |||||
multisite chronic pain | 1 | 1 | 1 | 26.6 | |||||
mathematical ability | 1 | 1 | 1 | 21.5 | |||||
smoking status measurement | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 49.5 | |||||
testosterone measurement | 1 | 37.6 | |||||
multisite chronic pain | 1 | 26.6 | |||||
mathematical ability | 1 | 21.5 | |||||
smoking status measurement | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | utrophin | VGNC:3784 | 463046 | |||||
Macaque | utrophin | 699498 | ||||||
Mouse | MGI:104631 | 22288 | ||||||
Rat | RGD:3947 | 25600 | ||||||
Dog | utrophin | VGNC:48215 | 442965 | |||||
Publication Statistics
PubMed Score 563.40
PubMed score by year
PubTator Score 198.89
PubTator score by year
Related Publications
Text Mined References (81)
GeneRif Annotations (37)
Items per page:
0 of 0
PMID | Year | Title |
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