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Tbio
UTP6
U3 small nucleolar RNA-associated protein 6 homolog

Protein Summary
Description
Involved in nucleolar processing of pre-18S ribosomal RNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261708
  • ENSP00000261708
  • ENSG00000108651

Symbol
  • C17orf40
  • HCA66
  • MHAT
  • HCA66
  • C17orf40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
kinase perturbation
0.84
hub protein
0.75
transcription factor perturbation
0.74
transcription factor binding site profile
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.28   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.28   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (369)
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.999998942
p_ni:  0.000001058
Score:  0.264
Data Source:  BioPlex,STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.999977306
p_ni:  0.000022694
Data Source:  BioPlex
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.999659287
p_ni:  0.000340677
p_wrong:  3.6e-8
Data Source:  BioPlex
TAF7L
Tbio
Novelty:  0.08132691
p_int:  0.99893918
p_ni:  0.000911798
p_wrong:  0.000149022
Score:  0.175
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.996350884
p_ni:  0.003625206
p_wrong:  0.00002391
Data Source:  BioPlex
IL4R
Tclin
Novelty:  0.00359183
p_int:  0.995155376
p_ni:  0.003534652
p_wrong:  0.001309972
Data Source:  BioPlex
DNAJB3
Tdark
p_int:  0.990763131
p_ni:  0.008740546
p_wrong:  0.000496323
Data Source:  BioPlex
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.99021741
p_ni:  0.009580465
p_wrong:  0.000202125
Data Source:  BioPlex
CDC123
Tbio
Novelty:  0.05599841
p_int:  0.98675196
p_ni:  0.013052883
p_wrong:  0.000195158
Data Source:  BioPlex
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.980542319
p_ni:  0.019277206
p_wrong:  0.000180476
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
40.7
1
1
0
1.1
7.3
albuminuria
1
1
0
34.1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
40.7
0
1.1
7.3
albuminuria
0
34.1
1.5
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UTP6, small subunit processome component
VGNC:9773
454568
Macaque
UTP6, small subunit processome component
713361
Mouse
MGI:2445193
216987
Rat
RGD:1311017
360574
Dog
UTP6, small subunit processome component
VGNC:48214
480616
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UTP6, small subunit processome component
Macaque
UTP6, small subunit processome component
Mouse
Rat
Dog
UTP6, small subunit processome component
Publication Statistics
PubMed Score 17.28
PubMed score by year
PubTator Score 3.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title