Tbio UTP3 Something about silencing protein 10

Protein Summary

Description

Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Uniprot Accession IDs

• Q9NQZ2
• Q6FI82

Gene Name

• UTP3

Ensembl ID

• ENST00000254803
• ENSP00000254803
• ENSG00000132467

Symbol

• CRLZ1
• SAS10
• CRL1
• CRLZ1
• SAS10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.96
transcription factor binding site profile	0.94
histone modification site profile	0.89
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Something About Silencing Protein 10

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Something About Silencing Protein 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.62   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.62   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0