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Tdark
UTP14C
U3 small nucleolar RNA-associated protein 14 homolog C

Protein Summary
Description
Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000521776
  • ENSP00000428619
  • ENSG00000253797

Symbol
  • KIAA0266
  • UTP14B
  • KIAA0266
  • 2700066J21Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.75
tissue
0.61
microRNA
0.6
transcription factor perturbation
0.54
PubMedID
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.58   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.58   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (287)
PNO1
Tbio
Novelty:  0.05311566
p_int:  0.999998147
p_ni:  0.00000181
p_wrong:  4.3e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
UTP14A
Tbio
Novelty:  0.06076507
p_int:  0.99887527
p_ni:  0.00112473
Score:  0.901
Data Source:  BioPlex,STRINGDB
LRP2
Tbio
Novelty:  0.00143258
p_int:  0.973117051
p_ni:  0.026882949
Data Source:  BioPlex
UTP6
Tbio
Novelty:  0.06525007
Score:  0.997
Data Source:  STRINGDB
WDR36
Tbio
Novelty:  0.02010676
Score:  0.996
Data Source:  STRINGDB
UTP4
Tbio
Novelty:  0.06989008
Score:  0.996
Data Source:  STRINGDB
PDCD11
Tbio
Novelty:  0.02209612
Score:  0.996
Data Source:  STRINGDB
TBL3
Tdark
Novelty:  0.05195885
Score:  0.996
Data Source:  STRINGDB
NOP14
Tbio
Novelty:  0.08903014
Score:  0.996
Data Source:  STRINGDB
DHX37
Tdark
Family:  Enzyme
Novelty:  0.02474351
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
52.4
mean corpuscular hemoglobin concentration
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
52.4
mean corpuscular hemoglobin concentration
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919804
72554
Rat
RGD:1359313
317579
Dog
UTP14A, small subunit processome component
492128
Horse
UTP14A, small subunit processome component
100058946
Cow
UTP14A, small subunit processome component
505324
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
UTP14A, small subunit processome component
Horse
UTP14A, small subunit processome component
Cow
UTP14A, small subunit processome component
Publication Statistics
PubMed Score 5.58
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title