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Tbio
UST
Uronyl 2-sulfotransferase

Protein Summary
Description
Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N-resulfated heparin. Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367463
  • ENSP00000356433
  • ENSG00000111962

Symbol
  • DS2ST
  • 2OST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.81
disease
0.73
histone modification site profile
0.7
PubMedID
0.69
microRNA
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.76   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.76   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
MRAP2
Tbio
Novelty:  0.0420503
p_int:  0.999983799
p_ni:  0.000016201
Data Source:  BioPlex
SLC27A6
Tbio
Family:  Transporter
Novelty:  0.01120087
p_int:  0.999039151
p_ni:  0.000960849
Score:  0.179
Data Source:  BioPlex,STRINGDB
INHBE
Tbio
Novelty:  0.07526145
p_int:  0.997206711
p_ni:  0.000843163
p_wrong:  0.001950126
Score:  0.183
Data Source:  BioPlex,STRINGDB
PPT2
Tbio
Family:  Enzyme
Novelty:  0.00829249
p_int:  0.994423012
p_ni:  0.005576988
Score:  0.175
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.958213868
p_ni:  0.041786132
Data Source:  BioPlex
DCAKD
Tdark
Family:  Enzyme
Novelty:  1.5418995
p_int:  0.944770063
p_ni:  0.055229937
Score:  0.179
Data Source:  BioPlex,STRINGDB
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.943347547
p_ni:  0.056652453
Data Source:  BioPlex
GLG1
Tbio
Novelty:  0.01332149
p_int:  0.939788286
p_ni:  0.060211714
Score:  0.15
Data Source:  BioPlex,STRINGDB
GOLIM4
Tbio
Novelty:  0.01923513
p_int:  0.936623102
p_ni:  0.063376897
p_wrong:  1e-9
Data Source:  BioPlex
XYLT2
Tbio
Family:  Enzyme
Novelty:  0.00273033
p_int:  0.930197642
p_ni:  0.069802339
p_wrong:  1.9e-8
Score:  0.521
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chondroitin sulfate/dermatan sulfate metabolism (R-HSA-1793185)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Dermatan sulfate biosynthesis
Reactome
Glycosaminoglycan metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Chondroitin sulfate/dermatan sulfate metabolism
Dermatan sulfate biosynthesis
Glycosaminoglycan metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
38.7
response to antidepressant
1
1
0
27
15.8
1
1
0
2.3
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
38.7
response to antidepressant
0
27
15.8
0
2.3
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uronyl 2-sulfotransferase
VGNC:8583
748624
Macaque
uronyl 2-sulfotransferase
697355
Mouse
MGI:2442406
338362
Rat
RGD:1304743
361450
Dog
uronyl 2-sulfotransferase
VGNC:48207
476238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uronyl 2-sulfotransferase
Macaque
uronyl 2-sulfotransferase
Mouse
Rat
Dog
uronyl 2-sulfotransferase
Publication Statistics
PubMed Score 30.76
PubMed score by year
PubTator Score 3.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title