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Tdark
USP9Y
Probable ubiquitin carboxyl-terminal hydrolase FAF-Y

Protein Summary
Description
May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity). This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338981
  • ENSP00000342812
  • ENSG00000114374

Symbol
  • DFFRY
  • DFFRY
  • SPGFY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
microRNA
0.68
PubMedID
0.62
biological process
0.58
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (8)
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.999931946
p_ni:  0.000068054
Data Source:  BioPlex
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.998863639
p_ni:  0.001136116
p_wrong:  2.45e-7
Data Source:  BioPlex
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
p_int:  0.993154202
p_ni:  0.006786168
p_wrong:  0.00005963
Data Source:  BioPlex
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.990383702
p_ni:  0.009616298
Data Source:  BioPlex
ZNF331
Tbio
Family:  TF
Novelty:  0.05976217
p_int:  0.988619237
p_ni:  0.011380763
Data Source:  BioPlex
C4orf47
Tdark
Novelty:  4.70710026
p_int:  0.94258648
p_ni:  0.055997545
p_wrong:  0.001415975
Data Source:  BioPlex
HS2ST1
Tbio
Family:  Enzyme
Novelty:  0.04520207
p_int:  0.942194494
p_ni:  0.057793229
p_wrong:  0.000012277
Data Source:  BioPlex
AKT2
Tchem
Family:  Kinase
Novelty:  0.00167027
p_int:  0.922537469
p_ni:  0.077444644
p_wrong:  0.000017888
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
20.9
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
20.9
21.5
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Fruitfly
FBgn0005632
43749
Species
Name
OMA
EggNOG
Inparanoid
Fruitfly
Publication Statistics
PubTator Score 29.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title