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Tbio
USP6NL
USP6 N-terminal-like protein

Protein Summary
Description
Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277575
  • ENSP00000277575
  • ENSG00000148429
  • ENST00000609104
  • ENSP00000476462

Symbol
  • KIAA0019
  • RNTRE
  • TRE2NL
  • USP6NL-IT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor
0.77
virus perturbation
0.76
histone modification site profile
0.75
tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.82   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0