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Tbio
USP6
Ubiquitin carboxyl-terminal hydrolase 6

Protein Summary
Description
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250066
  • ENSP00000250066
  • ENSG00000129204
  • ENST00000572949
  • ENSP00000461581
  • ENST00000574788
  • ENSP00000460380

Symbol
  • HRP1
  • TRE2
  • HRP1
  • TRE2
  • TRE17
  • Tre-2
  • TRESMCR
  • USP6-short
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.6
protein domain
0.58
microRNA
0.57
tissue sample
0.56
cell line
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.06   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 215.06   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0